Literature DB >> 19871057

THE ANTIGENIC POTENCY OF EPIDEMIC INFLUENZA VIRUS FOLLOWING INACTIVATION BY ULTRAVIOLET RADIATION.

J E Salk1, G I Lavin, T Francis.   

Abstract

A study of the antigenic potency of influenza virus inactivated by ultraviolet radiation has been made. Virus so inactivated is still capable of functioning as an immunizing agent when given to mice by the intraperitoneal route. In high concentrations inactivated virus appears to be nearly as effective as active virus but when quantitative comparisons of the immunity induced by different dilutions are made, it is seen that a hundredfold loss in immunizing capacity occurs during inactivation. Virus in suspensions prepared from the lungs of infected mice is inactivated more rapidly than virus in tissue culture medium. A standard for the comparison of vaccines of epidemic influenza virus is proposed.

Entities:  

Year:  1940        PMID： 19871057      PMCID： PMC2135045          DOI： 10.1084/jem.72.6.729

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  7 in total

1.  ANTIRABIC IMMUNIZATION WITH CULTURE VIRUS RENDERED AVIRULENT BY ULTRA-VIOLET LIGHT.

Authors:  H L Hodes; G I Lavin; L T Webster
Journal:  Science       Date:  1937-11-12       Impact factor: 47.728

2.  TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS.

Authors:  T Francis
Journal:  Science       Date:  1934-11-16       Impact factor: 47.728

3.  THE USE OF ULTRAVIOLET LIGHT IN PREPARING A NON-VIRULENT ANTIRABIES VACCINE.

Authors:  H L Hodes; L T Webster; G I Lavin
Journal:  J Exp Med       Date:  1940-09-30       Impact factor: 14.307

4.  ULTRA-VIOLET LIGHT AND VACCINE VIRUS : II. THE EFFECT OF MONOCHROMATIC ULTRA-VIOLET LIGHT UPON VACCINE VIRUS.

Authors:  T M Rivers; F L Gates
Journal:  J Exp Med       Date:  1928-01-01       Impact factor: 14.307

5.  THE INACTIVATION OF THE VIRUS OF EPIDEMIC INFLUENZA BY SOAPS.

Authors:  C C Stock; T Francis
Journal:  J Exp Med       Date:  1940-04-30       Impact factor: 14.307

6.  QUANTITATIVE RELATIONSHIPS BETWEEN THE IMMUNIZING DOSE OF EPIDEMIC INFLUENZA VIRUS AND THE RESULTANT IMMUNITY.

Authors:  T Francis
Journal:  J Exp Med       Date:  1939-01-31       Impact factor: 14.307

7.  PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR : II. THE INACTIVATION OF THE TUMOR-PRODUCING AGENT BY MONOCHROMATIC ULTRA-VIOLET LIGHT.

Authors:  E Sturm; F L Gates; J B Murphy
Journal:  J Exp Med       Date:  1932-02-29       Impact factor: 14.307
  7 in total
  9 in total

1.  Discovery and characterization of the 1918 pandemic influenza virus in historical context.

Authors:  Jeffery K Taubenberger; Johan V Hultin; David M Morens
Journal:  Antivir Ther       Date:  2007

2.  Studies on the inactivation of influenza virus; comparison of the effects of p-benzoquinone and various inorganic oxidizing agents.

Authors:  R R WAGNER
Journal:  Yale J Biol Med       Date:  1951-02

3.  THE EFFECT OF ULTRAVIOLET IRRADIATION ON VARIOUS PROPERTIES OF INFLUENZA VIRUSES.

Authors:  W Henle; G Henle
Journal:  J Exp Med       Date:  1947-03-31       Impact factor: 14.307

Review 4.  Characterization of Hemagglutinin Antigens on Influenza Virus and within Vaccines Using Electron Microscopy.

Authors:  John R Gallagher; Dustin M McCraw; Udana Torian; Neetu M Gulati; Mallory L Myers; Michael T Conlon; Audray K Harris
Journal:  Vaccines (Basel)       Date:  2018-05-25

5.  INTERFERENCE BETWEEN THE INFLUENZA VIRUSES : II. THE EFFECT OF VIRUS RENDERED NON-INFECTIVE BY ULTRAVIOLET RADIATION UPON THE MULTIPLICATION OF INFLUENZA VIRUSES IN THE CHICK EMBRYO.

Authors:  J E Ziegler; G I Lavin; F L Horsfall
Journal:  J Exp Med       Date:  1944-04-01       Impact factor: 14.307

6.  AN EVALUATION OF METHODS FOR THE CONCENTRATION AND PURIFICATION OF INFLUENZA VIRUS.

Authors:  W M Stanley
Journal:  J Exp Med       Date:  1944-03-01       Impact factor: 14.307

7.  STUDIES ON THE TOXICITY OF INFLUENZA VIRUSES : II. THE EFFECT OF INTRA-ABDOMINAL AND INTRAVENOUS INJECTION OF INFLUENZA VIRUSES.

Authors:  W Henle; G Henle
Journal:  J Exp Med       Date:  1946-11-30       Impact factor: 14.307

8.  THE PREPARATION AND PROPERTIES OF INFLUENZA VIRUS VACCINES CONCENTRATED AND PURIFIED BY DIFFERENTIAL CENTRIFUGATION.

Authors:  W M Stanley
Journal:  J Exp Med       Date:  1945-02-01       Impact factor: 14.307

9.  X-ray inactivation of RNA viruses without loss of biological characteristics.

Authors:  Babak Afrough; Jonathan Eakins; Sarah Durley-White; Stuart Dowall; Stephen Findlay-Wilson; Victoria Graham; Kuiama Lewandowski; Daniel P Carter; Roger Hewson
Journal:  Sci Rep       Date:  2020-12-08       Impact factor: 4.996
  9 in total

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