| Literature DB >> 19870664 |
H Okkels1.
Abstract
1. Perfusion of isolated thyroid glands from rabbits, made refractory to the action of the thyro-stimulating factor from the hypophysis by repeated injections for 2 months, has shown that in this condition the thyroid epithelium responds to pituitary stimulation. 2. The serum from refractory rabbits does not neutralize completely the thyro-stimulating effect of anterior pituitary extract upon an isolated normal thyroid gland. 3. It is believed that tissues other than the thyroid play a rôle in bringing about the phenomena which have been described as refractoriness against a prolonged action of the thyro-stimulating pituitary factor.Entities:
Year: 1937 PMID: 19870664 PMCID: PMC2133617 DOI: 10.1084/jem.66.3.305
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307