Literature DB >> 1987059

Median infective dose of Treponema pallidum determined in a highly susceptible guinea pig strain.

K Wicher1, V Wicher.   

Abstract

The median infective dose of Treponema pallidum subsp. pallidum and the production of immunity to reinfection in C4D guinea pigs have been determined with 10(1) to 10(6) organisms per infective dose. The mean infective dose is 10(2) organisms, and immunity--in those animals that demonstrated lesions--developed after 4.5 months postinfection.

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Year:  1991        PMID： 1987059      PMCID： PMC257764          DOI： 10.1128/iai.59.1.453-456.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Inoculation syphilis in human volunteers.

Authors:  H J MAGNUSON; E W THOMAS; S OLANSKY; B I KAPLAN; L DE MELLO; J C CUTLER
Journal:  Medicine (Baltimore)       Date:  1956-02       Impact factor: 1.889

Review 2.  Congenital syphilis: immunologic challenges.

Authors:  R E Baughn
Journal:  Pathol Immunopathol Res       Date:  1989

3.  Bactericidal and opsonic properties of C4-deficient guinea pig serum.

Authors:  R K Root; L Ellman; M M Frank
Journal:  J Immunol       Date:  1972-09       Impact factor: 5.422

4.  Immunogenicity of three recombinant Treponema pallidum antigens examined in guinea pigs.

Authors:  K Wicher; J D van Embden; L M Schouls; J Zabek; A Jakubowski; V Wicher
Journal:  Int Arch Allergy Appl Immunol       Date:  1989

5.  In vivo studies in C4-deficient guinea pigs.

Authors:  L Ellman; I Green; F Judge; M M Frank
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

6.  C4 synthesis in C4-deficient guinea pig radiation chimeras: restoration of the classic complement pathway.

Authors:  R O Webster; U H Rudofsky; R J Pickering
Journal:  J Immunol       Date:  1976-09       Impact factor: 5.422

7.  Adoptive transfer of immunity to Treponema pallidum Nichols infection in inbred strain 2 and C4D guinea pigs.

Authors:  V Wicher; K Wicher; A Jakubowski; S M Nakeeb
Journal:  Infect Immun       Date:  1987-10       Impact factor: 3.441

8.  Genetically controlled total deficiency of the fourth component of complement in the guinea pig.

Authors:  L Ellman; I Green; M Frank
Journal:  Science       Date:  1970-10-02       Impact factor: 47.728

Review 9.  Experimental syphilis in guinea pig.

Authors:  K Wicher; V Wicher
Journal:  Crit Rev Microbiol       Date:  1989       Impact factor: 7.624

10.  In vitro studies of complement function in sera of C4-deficient guinea pigs.

Authors:  M M Frank; J May; T Gaither; L Ellman
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307
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  4 in total

1.  Treponema pallidum subsp. pertenue displays pathogenic properties different from those of T. pallidum subsp. pallidum.

Authors:  K Wicher; V Wicher; F Abbruscato; R E Baughn
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

2.  Target organs of infection in guinea pigs with acquired congenital syphilis.

Authors:  K Wicher; F Abbruscato; V Wicher; R Baughn; G T Noordhoek
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

3.  A guinea pig model for Lyme disease.

Authors:  S W Sonnesyn; J C Manivel; R C Johnson; J L Goodman
Journal:  Infect Immun       Date:  1993-11       Impact factor: 3.441

4.  Immunization of guinea pigs with recombinant TmpB antigen induces protection against challenge infection with Treponema pallidum Nichols.

Authors:  K Wicher; L M Schouls; V Wicher; J D Van Embden; S S Nakeeb
Journal:  Infect Immun       Date:  1991-12       Impact factor: 3.441
  4 in total

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