THE STANDARDIZATION OF LONGEVITY AGAINST DOSE IN EXPERIMENTAL TUBERCULOSIS BY INTRACEREBRAL INOCULATION.

Intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. The disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. The disease is produced by very small numbers of bacilli; and under standard conditions, survival time is so uniform as to make possible quantitative or titration experiments. Certain possible applications of the method are discussed.