Literature DB >> 19870109

THE CELLULAR REACTIONS TO LIPOID FRACTIONS FROM ACID-FAST BACILLI.

K C Smithburn1, F R Sabin.   

Abstract

1. A comparative study has been made of the cellular reactions induced by phosphatides from five strains of acid-fast bacilli. Each of these reactions is characterized principally by epithelioid cells and giant cells. 2. The phosphatides are first phagocytized by young connective tissue cells or monocytes. The lipoid is then dispersed into fine particles with the formation of classical epithelioid cells. 3. A comparison has been made of the reactions induced by heat-killed and defatted tubercle bacilli with those induced by tuberculophosphatide. 4. Further studies have been made to determine whether or not the phosphatide causes sensitization to tuberculin. It does not do so. 5. The life cycle of the epithelioid cell has been observed in all its stages.

Entities:  

Year:  1932        PMID: 19870109      PMCID: PMC2132207          DOI: 10.1084/jem.56.6.867

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  5 in total

1.  The Effect of Tubercle Bacilli and the Chemical Fractions Obtained from Analysis on the Cells of the Connective Tissues in Rabbits.

Authors:  F R Sabin; C A Doan
Journal:  Proc Natl Acad Sci U S A       Date:  1927-07       Impact factor: 11.205

2.  SPECIAL ARTICLES.

Authors:  M Heidelberger; F E Kendall
Journal:  Science       Date:  1930-09-05       Impact factor: 47.728

3.  LOCAL PROGRESSION WITH SPONTANEOUS REGRESSION OF TUBERCULOSIS IN THE BONE MARROW OF RABBITS, CORRELATED WITH A TRANSITORY ANEMIA AND LEUCOPENIA AFTER INTRAVENOUS INOCULATION.

Authors:  C A Doan; F R Sabin
Journal:  J Exp Med       Date:  1927-07-31       Impact factor: 14.307

4.  THE BIOLOGICAL REACTIONS IN RABBITS TO THE PROTEIN AND PHOSPHATIDE FRACTIONS FROM THE CHEMICAL ANALYSIS OF HUMAN TUBERCLE BACILLI.

Authors:  F R Sabin; C A Doan
Journal:  J Exp Med       Date:  1927-09-30       Impact factor: 14.307

5.  THE INDUCED DEVELOPMENT AND HISTOGENESIS OF PLASMA CELLS.

Authors:  F R Miller
Journal:  J Exp Med       Date:  1931-07-31       Impact factor: 14.307

  5 in total
  12 in total

1.  [Animal experimental studies on the problem of epitheloid cell formation in normal and tuberculous organisms with special reference to tuberculin allergy].

Authors:  H R GERBER
Journal:  Arch Klin Exp Dermatol       Date:  1958

2.  Experimental Tuberculosis in Mice: The Cellular Response to the Chemical Fractions of the Tubercle Bacillus.

Authors:  R M Thomas; F I Dessau
Journal:  Yale J Biol Med       Date:  1939-12

3.  Studies in the Pathology of Vascular Disease: The Response of the Rabbit's Carotid Artery to Injuries-Effect of Injection of Tubercle Bacilli and of Colloidal Cholesterol.

Authors:  D W Gaiser; P M Lecompte
Journal:  Yale J Biol Med       Date:  1936-10

4.  CELLULAR REACTIONS TO TUBERCULO-PROTEINS COMPARED WITH THE REACTIONS TO TUBERCULO-LIPIDS.

Authors:  F R Sabin
Journal:  J Exp Med       Date:  1938-10-31       Impact factor: 14.307

5.  CELLULAR REACTIONS TO A DYE-PROTEIN WITH A CONCEPT OF THE MECHANISM OF ANTIBODY FORMATION.

Authors:  F R Sabin
Journal:  J Exp Med       Date:  1939-06-30       Impact factor: 14.307

6.  Studies of a carbohydrate-lipoid complex from the human strain tubercle bacillus H37.

Authors:  G V KROPP; C FLOYD
Journal:  Yale J Biol Med       Date:  1947-10

7.  CELLULAR REACTIONS TO DEFATTED TUBERCLE BACILLI AND THEIR PRODUCTS.

Authors:  F R Sabin; A L Joyner
Journal:  J Exp Med       Date:  1938-10-31       Impact factor: 14.307

8.  TUBERCULAR ALLERGY WITHOUT INFECTION.

Authors:  F R Sabin; A L Joyner
Journal:  J Exp Med       Date:  1938-10-31       Impact factor: 14.307

9.  QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : ANTIBODY PRODUCTION IN RABBITS INJECTED WITH AN AZO PROTEIN.

Authors:  M Heidelberger; F E Kendall; C M Soo Hoo
Journal:  J Exp Med       Date:  1933-07-31       Impact factor: 14.307

10.  THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT.

Authors:  K C Smithburn; F R Sabin
Journal:  J Exp Med       Date:  1935-05-31       Impact factor: 14.307

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