Literature DB >> 19870087

STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES.

H M Klein1.   

Abstract

Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity. A similar modification occurs spontaneously in meningococcus culture filtrates on standing. Inasmuch as these changes parallel those occurring in the conversion of diphtheria toxin into toxoid, it is justifiable to consider such altered meningococcus toxin as meningococcus toxoid.

Entities:  

Year:  1932        PMID： 19870087      PMCID： PMC2132186          DOI： 10.1084/jem.56.4.587

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  4 in total

1.  STUDIES ON BACILLUS TYPHOSUS TOXIC SUBSTANCES : III. THE EFFECT OF SERA UPON THE INJURY PRODUCING FACTORS OF THE PHENOMENON OF LOCAL SKIN REACTIVITY.

Authors:  G Shwartzman
Journal:  J Exp Med       Date:  1929-09-30       Impact factor: 14.307

2.  PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: AN ANTIBODY AUXILIARY TO SERUM NEUTRALIZATION OF MENINGOCOCCUS REACTING FACTORS.

Authors:  G Shwartzman
Journal:  J Exp Med       Date:  1931-10-31       Impact factor: 14.307

3.  CONCERNING THE SPECIFICITY AND NATURE OF THE PHENOMENON OF LOCAL SKIN REACTIVITY TO VARIOUS BACTERIAL FILTRATES.

Authors:  G Shwartzman
Journal:  J Exp Med       Date:  1930-03-31       Impact factor: 14.307

4.  STUDIES ON BACILLUS TYPHOSUS TOXIC SUBSTANCES : I. PHENOMENON OF LOCAL SKIN REACTIVITY TO B. TYPHOSUS CULTURE FILTRATE.

Authors:  G Shwartzman
Journal:  J Exp Med       Date:  1928-07-31       Impact factor: 14.307
  4 in total

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