THE EFFECT OF PROTEIN SPLIT PRODUCTS ON THE SERUM FERMENTS AND ANTIFERMENT : STUDIES ON FERMENT ACTION. XXVI.

1. In dogs the toxic effect of primary proteoses is usually associated with the following serum changes: (a) an increase in serum antiferment, with a following fall in titer; (b) some increase in serum protease; (c) an increase in serum lipase; (d) a decrease in serum proteoses and amino nitrogen. 2. Secondary proteoses produce (a) less marked changes in the antiferment titer; (b) a marked increase in serum protease; (c) an increase in serum proteoses; (d) only a slight change in serum lipase; (e) a primary decrease in amino nitrogen. 3. The peptone which we have used (prepared from dog muscle) caused (a) a change in antiferment titer similar to that produced by the primary proteoses; (b) a marked increase in serum protease; (c) only a slight increase in serum lipase; (d) a primary decrease in proteoses, followed by an increase later; (e) an increase in amino-acids. 4. A very small dose of peptone resulted in a decrease in antiferment titer, together with a primary decrease in serum protease. 5. The peptone preparation was non-toxic when introduced into the stomach or rectum, while the intestinal injection was followed by an immediate intoxication.