Literature DB >> 1986791

Proteolytic modification of neural cell adhesion molecule (NCAM) by the intracellular proteinase calpain.

A Sheppard1, J Wu, U Rutishauser, G Lynch.   

Abstract

The neural cell adhesion molecule, NCAM, is concentrated in synaptic regions and thus may contribute to the formation and maintenance of connections between brain cells. We present evidence that the cytoplasmic domain of NCAM can be experimentally modified by the intracellular calcium-dependent proteinase, calpain. This degradation could provide a mechanism for rapidly uncoupling and reorganizing synaptic contacts.

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Year:  1991        PMID： 1986791     DOI： 10.1016/0167-4838(91)90234-q

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  4 in total

1.  Effect of voltage drop within the synaptic cleft on the current and voltage generated at a single synapse.

Authors:  L P Savtchenko; S N Antropov; S M Korogod
Journal:  Biophys J       Date:  2000-03       Impact factor: 4.033

2.  Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: pharmacological studies and the characterization of a candidate matrix receptor.

Authors:  B A Bahr; U Staubli; P Xiao; D Chun; Z X Ji; E T Esteban; G Lynch
Journal:  J Neurosci       Date:  1997-02-15       Impact factor: 6.167

Review 3.  Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.

Authors:  O S Jørgensen
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

4.  Contractile activity regulates isoform expression and polysialylation of NCAM in cultured myotubes: involvement of Ca2+ and protein kinase C.

Authors:  V F Rafuse; L Landmesser
Journal:  J Cell Biol       Date:  1996-03       Impact factor: 10.539
  4 in total

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