Literature DB >> 198678

Iontrophoretic application of autonomic mediators and cyclic nucleotides in the sinus node cells.

W Tuganowski, P Kopeć, M Kopyta, J Weźowska.   

Abstract

The effects of intracellular application of noradrenaline, acetylcholine, cAMP and cGMP were studied in the sinus-node of the rabbit. Noradrenaline and acetylcholine were without effect on electrical activity. In about one third of cases, cAMP increased, and cGMP decreased the slope of slow depolarization. These results suggest that adrenergic as well as cholinergic receptors which control the electrical activity of the sinus node cell are localized at the outer side of the cell membrane. It has also been shown that the cyclic nucleotides exert direct but opposite chronotropic effects.

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Year:  1977        PMID： 198678     DOI： 10.1007/bf00508639

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  7 in total

1.  On the localization of acetylcholine receptors.

Authors:  J DEL CASTILLO; B KATZ
Journal:  J Physiol       Date:  1955-04-28       Impact factor: 5.182

2.  Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres.

Authors:  R W Tsien
Journal:  Nat New Biol       Date:  1973-09-26

3.  A study of the bioloical activity and resistance to phosphodiesterase of some derivatives and analogues of cyclic AMP.

Authors:  G Cehovic; T Posternak; E Charollais
Journal:  Adv Cyclic Nucleotide Res       Date:  1972

4.  Adenyl cyclase and cyclic AMP. Biochemical links in the regulation of myocardial contractility.

Authors:  S E Epstein; G S Levey; C L Skelton
Journal:  Circulation       Date:  1971-03       Impact factor: 29.690

5.  Simple method of stimulation and recording with a single microelectrode.

Authors:  W Tuganowski
Journal:  J Appl Physiol       Date:  1972-07       Impact factor: 3.531

6.  Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.

Authors:  H Reuter
Journal:  J Physiol       Date:  1974-10       Impact factor: 5.182

7.  Effects of intracellularly applied cyclic 3',5'-adenosine monophosphate and dibutyryl cyclic 3',5'-adenosine monophosphate on the electrical activity of sinoatrial nodal cells of the rabbit.

Authors:  Y Yamasaki; M Fujiwara; N Toda
Journal:  J Pharmacol Exp Ther       Date:  1974-07       Impact factor: 4.030
  7 in total
  2 in total

1.  The effect of cGMP in rabbit auricle as studied by a cut-end method.

Authors:  W Tuganowski; P Kopeć
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-10       Impact factor: 3.000

2.  Are acetylcholine-induced increases in 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace-maker tissue?

Authors:  B P Fleming; W Giles; J Lederer
Journal:  J Physiol       Date:  1981-05       Impact factor: 5.182
  2 in total

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