Literature DB >> 1986735

A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.

G R Reddy1, N Ueda, T Hada, A C Sackeyfio, S Yamamoto, Y Hano, M Aida, T Nomura.   

Abstract

Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).

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Year:  1991        PMID： 1986735     DOI： 10.1016/0006-2952(91)90018-z

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

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Authors:  Mashitoh Abd Rahman; Faiqah Ramli; Hamed Karimian; Firouzeh Dehghan; Noraziah Nordin; Hapipah Mohd Ali; Syam Mohan; Najihah Mohd Hashim
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3.  The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells.

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Journal:  PLoS One       Date:  2017-08-03       Impact factor: 3.240

4.  Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells.

Authors:  Imaobong Christopher Etti; Abdullah Rasedee; Najihah Mohd Hashim; Ahmad Bustamam Abdul; Arifah Kadir; Swee Keong Yeap; Peter Waziri; Ibrahim Malami; Kian Lam Lim; Christopher J Etti
Journal:  Drug Des Devel Ther       Date:  2017-03-20       Impact factor: 4.162

Review 5.  Molecular mechanism underlying anti-inflammatory and anti-allergic activities of phytochemicals: an update.

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Review 6.  The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus.

Authors:  Dong Wook Choi; Sang Woo Cho; Seok-Geun Lee; Cheol Yong Choi
Journal:  Int J Mol Sci       Date:  2020-09-07       Impact factor: 5.923

7.  Anti-Inflammatory Effects of Hyptis albida Chloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages.

Authors:  Elizabeth Sánchez Miranda; Julia Pérez Ramos; Cristina Fresán Orozco; Miguel Angel Zavala Sánchez; Salud Pérez Gutiérrez
Journal:  ISRN Pharmacol       Date:  2013-07-22
  7 in total

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