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Literature DB >> 19867230

STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE.

Abstract

Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measurable effect. The results suggest that the antibody response in this in vitro system depends upon cell multiplication during this period.

Entities: Chemical Species

Year: 1963 PMID： 19867230 PMCID： PMC2137596 DOI： 10.1084/jem.117.6.1063

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

1. Enzymatic synthesis of deoxyribonucleic acid. X. Influence of bromouracil substitutions on replication.

Authors: T A TRAUTNER; M N SWARTZ; A KORNBERG
Journal: Proc Natl Acad Sci U S A Date: 1962-03-15 Impact factor: 11.205

2. Effect of 5-bromodeoxyuridine on mamalian chromosomes.

Authors: T C HSU; C E SOMERS
Journal: Proc Natl Acad Sci U S A Date: 1961-03-15 Impact factor: 11.205

3. Autoradiographic observations of plasma cell formation.

Authors: J C SCHOOLEY
Journal: J Immunol Date: 1961-03 Impact factor: 5.422

4. The effect of 5-bromouracil deoxyriboside on the synthesis of antibody in vitro.

Authors: R W DUTTON; A H DUTTON; J H VAUGHAN
Journal: Biochem J Date: 1960-05 Impact factor: 3.857

5. The toxic effect of 5-bromodeoxyuridine on cultured epithelial cells.

Authors: J W LITTLEFIELD; E A GOULD
Journal: J Biol Chem Date: 1960-04 Impact factor: 5.157

6. Effects of 5-halogenated uracils on the growth of Escherichia coli and their incorporation into deoxyribonucleic acids.

Authors: D B DUNN; J D SMITH
Journal: Biochem J Date: 1957-11 Impact factor: 3.857

7. Induced gene unstabilization.

Authors: S ZAMENHOF; R DE GIOVANNI; S GREER
Journal: Nature Date: 1958-03-22 Impact factor: 49.962

8. Effect of 5-bromodeoxyuridine on deoxyribonucleic acid-thymine synthesis and cell metabolism of lymphatic tissues and tumors.

Authors: S KIT; C BECK; O L GRAHAM; A GROSS
Journal: Cancer Res Date: 1958-06 Impact factor: 12.701

9. Production of bacteriophage mutants by a disturbance of deoxyribonucleic acid metabolism.

Authors: R M LITMAN; A B PARDEE
Journal: Nature Date: 1956-09-08 Impact factor: 49.962

10. Conservation of desoxyribonucleic acid phosphorus in animal cells propagated in vitro.

Authors: G M HEALY; L SIMINOVITCH; R C PARKER; A F GRAHAM
Journal: Biochim Biophys Acta Date: 1956-05

11 in total

1. In vitro anamnestic immune responses and modulating factors.

Authors: A B Stavitsky; A A Gerblich
Journal: Mol Cell Biochem Date: 1979-12-14 Impact factor: 3.396

2. Relationship of germinal centers in lymphoid tissue to immunological memory. II. The detection of primed cells and their proliferation upon cell transfer to lethally irradiated syngeneic mice.

Authors: J D Wakefield; G J Thorbecke
Journal: J Exp Med Date: 1968-07-01 Impact factor: 14.307

3. The X-Y-Z scheme of immunocyte maturation. VII. Cell division and the establishment of short-term IgM memory.

Authors: P Byfield; E Sercarz
Journal: J Exp Med Date: 1969-05-01 Impact factor: 14.307

4. Studies of PPLO infection. V. Inhibition of lymphocyte mitosis and antibody formation by mycoplasmal extracts.

Authors: M S Simberkoff; G J Thorbecke; L Thomas
Journal: J Exp Med Date: 1969-06-01 Impact factor: 14.307

5. The proliferative and anamnestic antibody response of rabbit lymphoid cells in vitro. I. Immunological memory in the lymph nodes draining and contralateral to the site of a primary antigen injection.

Authors: E B Jacobson; G J Thorbecke
Journal: J Exp Med Date: 1969-08-01 Impact factor: 14.307

6. High-dose delay of the immune response. Effect of actinomycin D on continuation of the immune response in vitro.

Authors: J Iványi; M Maler; L Wudl; E Sercarz
Journal: J Exp Med Date: 1968-06-01 Impact factor: 14.307

7. Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.

Authors: R W Dutton; R I Mishell
Journal: J Exp Med Date: 1967-09-01 Impact factor: 14.307

8. Cellular differentiation of the immune system of mice. II. Frequency of unipotent splenic antigen-sensitive units after immunization with sheep erythrocytes.

Authors: G M Shearer; G Cudkowicz; R L Priore
Journal: J Exp Med Date: 1969-01-01 Impact factor: 14.307

9. EFFECT OF ACTINOMYCIN D ON RNA SYNTHESIS AND ANTIBODY FORMATION IN THE ANAMNESTIC RESPONSE IN VITRO.

Authors: J D Smiley; J G Heard; M Ziff
Journal: J Exp Med Date: 1964-06-01 Impact factor: 14.307

10. Gamma globulin and antibody formation in vitro. VII. Effect of x-irradiation on the secondary antibody response in vitro.

Authors: V J Stecher; G J Thorbecke
Journal: J Exp Med Date: 1967-01-01 Impact factor: 14.307