Literature DB >> 19867174

THE EFFECT OF DIPHTHERIA TOXIN ON THE METABOLISM OF HELA CELLS : II. EFFECT ON NUCLEIC ACID METABOLISM.

N Strauss1.   

Abstract

The effect of toxin on the incorporation of uridine and thymidine into nucleic acids was investigated. P(32) orthophosphate incorporation into the nucleoside phosphate fraction was also investigated. No early effect of toxin on nucleic acid synthesis was evident and only a slight effect of toxin on nucleoside phosphate formation was found prior to 1.5 hours after toxin addition. Both these processes, however, were found to be sensitive to dinitrophenol. These results are interpreted as indicating that toxin does not act by a general uncoupling of oxidation from phosphorylation. Other possible mechanisms of toxin action are proposed.

Entities:  

Year:  1960        PMID： 19867174      PMCID： PMC2137219          DOI： 10.1084/jem.112.2.351

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  9 in total

1.  A new culture method designed for kinetic studies on diphtheria toxin production.

Authors:  M YONEDA
Journal:  Br J Exp Pathol       Date:  1957-04

2.  The effect of arsenate on aerobic phosphorylation.

Authors:  R K CRANE; F LIPMANN
Journal:  J Biol Chem       Date:  1953-03       Impact factor: 5.157

3.  Studies on Diphtheria Toxin and Its Reaction with Antitoxin.

Authors:  A M Pappenheimer
Journal:  J Bacteriol       Date:  1942-03       Impact factor: 3.490

4.  The effects of diphtheria toxin on the Cecropia silkworm.

Authors:  A M PAPPENHEIMER; C M WILLIAMS
Journal:  J Gen Physiol       Date:  1952-05       Impact factor: 4.086

5.  STUDIES ON THE MOLECULAR WEIGHT OF DIPHTHERIA TOXIN, ANTITOXIN, AND THEIR REACTION PRODUCTS.

Authors:  A M Pappenheimer; H P Lundgren; J W Williams
Journal:  J Exp Med       Date:  1940-01-31       Impact factor: 14.307

6.  Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer.

Authors:  T T PUCK; P I MARCUS; S J CIECIURA
Journal:  J Exp Med       Date:  1956-02-01       Impact factor: 14.307

7.  The specific amino acid requirements of a human carcinoma cell (Stain HeLa) in tissue culture.

Authors:  H EAGLE
Journal:  J Exp Med       Date:  1955-07-01       Impact factor: 14.307

8.  Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix.

Authors:  W F SCHERER; J T SYVERTON; G O GEY
Journal:  J Exp Med       Date:  1953-05       Impact factor: 14.307

9.  The effect of diphtheria toxin on the metabolism of HeLa cells.

Authors:  N STRAUSS; E D HENDEE
Journal:  J Exp Med       Date:  1959-02-01       Impact factor: 14.307
  9 in total
  7 in total

1.  Pinocytosis of diphtheria toxin by different types of human cells cultured in vitro.

Authors:  F Paradisi
Journal:  Med Microbiol Immunol       Date:  1974       Impact factor: 3.402

2.  Toxic proteins inhibiting protein synthesis.

Authors:  S Olsnes
Journal:  Naturwissenschaften       Date:  1972-11

3.  Studies of the Biologic Activity of Purified Staphylococcal Alpha-Toxin: I. The Effect of Alpha-Toxin on Cells in Tissue Culture.

Authors:  M S Artenstein; M A Madoff; L Weinstein
Journal:  Yale J Biol Med       Date:  1963-04

4.  STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN. I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS.

Authors:  R J COLLIER; A M PAPPENHEIMER
Journal:  J Exp Med       Date:  1964-12-01       Impact factor: 14.307

5.  STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN. II. EFFECT OF TOXIN ON AMINO ACID INCORPORATION IN CELL-FREE SYSTEMS.

Authors:  R J COLLIER; A M PAPPENHEIMER
Journal:  J Exp Med       Date:  1964-12-01       Impact factor: 14.307

6.  An early effect of diphtheria toxin on the metabolism of mammalian cells growing in culture.

Authors:  I KATO; A M PAPPENHEIMER
Journal:  J Exp Med       Date:  1960-08-01       Impact factor: 14.307

7.  The response of cultured mammalian cells to diphtheria toxin. I. Amino acid transport, accumulation, and incorporation in normal and intoxicated sensitive cells.

Authors:  T J Moehring; J M Moehring; R J Kuchler; M Solotorovsky
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307
  7 in total

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