Literature DB >> 19865468

A New Antimalarial Polyether from a Marine Streptomyces sp. H668.

Minkyun Na1, Damaris A F Meujo, Dion Kevin, Mark T Hamann, Matthew Anderson, Russell T Hill.   

Abstract

The antimalarial guided fractionation of the culture of marine Streptomyces sp. strain H668 led to the isolation of a new polyether metabolite. The structure was determined by comprehensive NMR and MS assignments. This new metabolite showed in vitro antimalarial activity against both the chloroquine-susceptible (D6) and -resistant (W2) clones of Plasmodium falciparum, without cytotoxicity to normal cells (Vero) making it a promising first lead from this marine bacterium.

Entities:  

Year:  2008        PMID： 19865468      PMCID： PMC2577051          DOI： 10.1016/j.tetlet.2008.08.052

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  12 in total

1.  Averting a malaria disaster.

Authors:  N J White; F Nosten; S Looareesuwan; W M Watkins; K Marsh; R W Snow; G Kokwaro; J Ouma; T T Hien; M E Molyneux; T E Taylor; C I Newbold; T K Ruebush; M Danis; B M Greenwood; R M Anderson; P Olliaro
Journal:  Lancet       Date:  1999-06-05       Impact factor: 79.321

2.  In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia.

Authors:  Kazuhiko Otoguro; Aki Ishiyama; Hideaki Ui; Miyuki Kobayashi; Chizu Manabe; Guan Yan; Yoko Takahashi; Haruo Tanaka; Haruki Yamada; Satoshi Omura
Journal:  J Antibiot (Tokyo)       Date:  2002-09       Impact factor: 2.649

3.  Studies on marine microorganisms. V. A new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud.

Authors:  Y Okami; T Okazaki; T Kitahara; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1976-10       Impact factor: 2.649

4.  Structure of K-41B, a new diglycoside polyether antibiotic.

Authors:  N Tsuji; K Nagashima; Y Terui; K Tori
Journal:  J Antibiot (Tokyo)       Date:  1979-02       Impact factor: 2.649

5.  Arenaric acid, a new pentacyclic polyether produced by a marine bacterium (Actinomycetales).

Authors:  X C Cheng; P R Jensen; W Fenical
Journal:  J Nat Prod       Date:  1999-04       Impact factor: 4.050

6.  Potent antimalarial activities of polyether antibiotic, X-206.

Authors:  K Otoguro; A Kohana; C Manabe; A Ishiyama; H Ui; K Shiomi; H Yamada; S Omura
Journal:  J Antibiot (Tokyo)       Date:  2001-08       Impact factor: 2.649

7.  Characterization of the potent in vitro and in vivo antimalarial activities of ionophore compounds.

Authors:  C Gumila; M L Ancelin; A M Delort; G Jeminet; H J Vial
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

8.  Differential in vitro activities of ionophore compounds against Plasmodium falciparum and mammalian cells.

Authors:  C Gumila; M L Ancelin; G Jeminet; A M Delort; G Miquel; H J Vial
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

9.  The structure of CP-96,797, a polyether antibiotic related to K-41A and produced by Streptomyces sp.

Authors:  J P Dirlam; J Bordner; W P Cullen; M T Jefferson; L Presseau-Linabury
Journal:  J Antibiot (Tokyo)       Date:  1992-07       Impact factor: 2.649

10.  Synthesis, structure and antimicrobial activity of manganese(II) and cobalt(II) complexes of the polyether ionophore antibiotic Sodium Monensin A.

Authors:  Petar Dorkov; Ivayla N Pantcheva; William S Sheldrick; Heike Mayer-Figge; Rositza Petrova; Mariana Mitewa
Journal:  J Inorg Biochem       Date:  2007-07-01       Impact factor: 4.155
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  4 in total

Review 1.  The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules.

Authors:  Katharine R Watts; Karen Tenney; Phillip Crews
Journal:  Curr Opin Biotechnol       Date:  2010-10-16       Impact factor: 9.740

Review 2.  Marine antimalarials.

Authors:  Ernesto Fattorusso; Orazio Taglialatela-Scafati
Journal:  Mar Drugs       Date:  2009-04-23       Impact factor: 5.118

3.  Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.

Authors:  Dion A Kevin Ii; Damaris Af Meujo; Mark T Hamann
Journal:  Expert Opin Drug Discov       Date:  2009-02       Impact factor: 6.098

Review 4.  Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Nobuhiro Fusetani
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2010-09-15       Impact factor: 3.228
  4 in total

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