Literature DB >> 19864378

Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease.

Kien Chai Ong1, Shamala Devi, Mary Jane Cardosa, Kum Thong Wong.   

Abstract

Enterovirus 71 (EV71) causes childhood hand, foot, and mouth disease and neurological complications, and no vaccines or therapeutic drugs are currently available. Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse model of EV71 encephalomyelitis. After only two immunizations, given to mice at 1 and 7 days of age, the MAV vaccine protected mice at 14 days of age from disease. Tissues from immunized mice were negative for virus by viral culture, reverse transcriptase PCR, immunohistochemistry analysis, and in situ hybridization. Cross-neutralizing EV71 antibodies to strains with genotypes B3, B4, and C1 to C5 generated in immunized adult mice were able to passively protect 14-day-old mice from disease.

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Year:  2010        PMID： 19864378      PMCID： PMC2798416          DOI： 10.1128/JVI.00999-09

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

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Journal:  JAMA       Date:  1988-03-18       Impact factor: 56.272

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Journal:  N Engl J Med       Date:  1999-09-23       Impact factor: 91.245

4.  Outbreak of severe neurologic involvement associated with Enterovirus 71 infection.

Authors:  H Komatsu; Y Shimizu; Y Takeuchi; H Ishiko; H Takada
Journal:  Pediatr Neurol       Date:  1999-01       Impact factor: 3.372

5.  Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system.

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Journal:  Arch Dis Child       Date:  1980-08       Impact factor: 3.791

6.  Fatal enterovirus 71 encephalomyelitis.

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Journal:  J Pediatr       Date:  1998-12       Impact factor: 4.406

7.  The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways.

Authors:  Kum Thong Wong; Badmanathan Munisamy; Kien Chai Ong; Hideaki Kojima; Nagata Noriyo; Kaw Bing Chua; Beng Beng Ong; Kazuo Nagashima
Journal:  J Neuropathol Exp Neurol       Date:  2008-02       Impact factor: 3.685

8.  Enterovirus 71 infections and neurologic disease--United States, 1977-1991.

Authors:  J P Alexander; L Baden; M A Pallansch; L J Anderson
Journal:  J Infect Dis       Date:  1994-04       Impact factor: 5.226

9.  Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years.

Authors:  Yuwana Podin; Edna L M Gias; Flora Ong; Yee-Wei Leong; Siew-Fung Yee; Mohd Apandi Yusof; David Perera; Bibiana Teo; Thian-Yew Wee; Sik-Chi Yao; Sik-King Yao; Andrew Kiyu; Mohd Taha Arif; Mary Jane Cardosa
Journal:  BMC Public Health       Date:  2006-07-07       Impact factor: 3.295

10.  Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005.

Authors:  Phan Van Tu; Nguyen Thi Thanh Thao; David Perera; Khanh Huu Truong; Nguyen Thi Kim Tien; Tang Chi Thuong; Ooi Mong How; Mary Jane Cardosa; Peter Charles McMinn
Journal:  Emerg Infect Dis       Date:  2007-11       Impact factor: 6.883
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  53 in total

1.  Forecasting the economic value of an Enterovirus 71 (EV71) vaccine.

Authors:  Bruce Y Lee; Angela R Wateska; Rachel R Bailey; Julie H Y Tai; Kristina M Bacon; Kenneth J Smith
Journal:  Vaccine       Date:  2010-10-16       Impact factor: 3.641

2.  Development of a sandwich ELISA for the quantification of enterovirus 71.

Authors:  Shujun Ma; Qunying Mao; Zhenglun Liang; Cuijuan Zhang; Wenxing Yang; Zhe Sun; Haijiang Zhang; Xinliang Shen; Shengli Bi; Le Sun
Journal:  Cytotechnology       Date:  2013-06-02       Impact factor: 2.058

3.  The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems.

Authors:  Wen Qi An; Zhi Guo Su; Ruo Wen Pan; Bao Ping Yang; Yong Chao Zhang; Liang Shi; Qing Li
Journal:  Hum Vaccin Immunother       Date:  2014-01-08       Impact factor: 3.452

4.  Protective Efficacies of Formaldehyde-Inactivated Whole-Virus Vaccine and Antivirals in a Murine Model of Coxsackievirus A10 Infection.

Authors:  Zhenjie Zhang; Zhaopeng Dong; Juan Li; Michael J Carr; Dongming Zhuang; Jianxing Wang; Yawei Zhang; Shujun Ding; Yigang Tong; Dong Li; Weifeng Shi
Journal:  J Virol       Date:  2017-06-09       Impact factor: 5.103

5.  Cryo-electron microscopy study of insect cell-expressed enterovirus 71 and coxsackievirus a16 virus-like particles provides a structural basis for vaccine development.

Authors:  Minqing Gong; Hongtao Zhu; Jun Zhou; Chunting Yang; Jing Feng; Xiaojun Huang; Gang Ji; Honglin Xu; Ping Zhu
Journal:  J Virol       Date:  2014-03-26       Impact factor: 5.103

6.  Transgenic mouse model for the study of enterovirus 71 neuropathogenesis.

Authors:  Ken Fujii; Noriyo Nagata; Yuko Sato; Kien Chai Ong; Kum Thong Wong; Seiya Yamayoshi; Midori Shimanuki; Hiroshi Shitara; Choji Taya; Satoshi Koike
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-19       Impact factor: 11.205

Review 7.  Therapeutic and prevention strategies against human enterovirus 71 infection.

Authors:  Chee Choy Kok
Journal:  World J Virol       Date:  2015-05-12

8.  Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice.

Authors:  Shiyang Sun; Liping Jiang; Zhenglun Liang; Qunying Mao; Weiheng Su; Huafei Zhang; Xiaojun Li; Jun Jin; Lin Xu; Dandan Zhao; Peihu Fan; Dong An; Ping Yang; Jingcai Lu; Xiuping Lv; Bo Sun; Fei Xu; Wei Kong; Chunlai Jiang
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

9.  Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene.

Authors:  Kok Keng Tee; Tommy Tsan-Yuk Lam; Yoke Fun Chan; Jon M Bible; Adeeba Kamarulzaman; C Y William Tong; Yutaka Takebe; Oliver G Pybus
Journal:  J Virol       Date:  2010-01-20       Impact factor: 5.103

Review 10.  Progress on the research and development of human enterovirus 71 (EV71) vaccines.

Authors:  Zhenglun Liang; Qunying Mao; Fan Gao; Junzhi Wang
Journal:  Front Med       Date:  2012-12-17       Impact factor: 4.592
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