Literature DB >> 19863154

Selective synthesis of 1-functionalized-alkyl-1H-indazoles.

Kevin W Hunt1, David A Moreno, Nicole Suiter, Christopher T Clark, Ganghyeok Kim.   

Abstract

An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.

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Year:  2009        PMID： 19863154     DOI： 10.1021/ol902050m

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Access to α-Pyrazole and α-Triazole Derivatives of Ketones from Oxidative Heteroarylation of Silyl Enolethers.

Authors:  Sandeep Dhanju; Aidan C Caravana; Regan J Thomson
Journal:  Org Lett       Date:  2020-10-01       Impact factor: 6.005

2.  Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles.

Authors:  Mei-Huey Lin; Kung-Yu Liang; Chang-Hsien Tsai; Yu-Chun Chen; Hung-Chang Hsiao; Yi-Syuan Li; Chung-Hao Chen; Hau-Chun Wu
Journal:  Molecules       Date:  2016-02-19       Impact factor: 4.411

3.  Synthesis of indazoles from 2-formylphenylboronic acids.

Authors:  Vitalii V Solomin; Alberts Seins; Aigars Jirgensons
Journal:  RSC Adv       Date:  2021-06-28       Impact factor: 3.361

4.  The 2-alkyl-2H-indazole regioisomers of synthetic cannabinoids AB-CHMINACA, AB-FUBINACA, AB-PINACA, and 5F-AB-PINACA are possible manufacturing impurities with cannabimimetic activities.

Authors:  Mitchell Longworth; Samuel D Banister; James B C Mack; Michelle Glass; Mark Connor; Michael Kassiou
Journal:  Forensic Toxicol       Date:  2016-04-27       Impact factor: 4.096
  4 in total

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