OBJECTIVE: To assess Chinese women's preference for the choice of a prenatal diagnosis test, karyotyping or rapid aneuploidy, and its relationship to maternal psychological state. STUDY DESIGN: Three hundred consenting women completed a self administered structured questionnaire which documented their psychological state and their preferred choice of diagnostic test for chromosomal abnormality using a discrete choice experiment design. Diagnostic tests were categorised according to three attributes: completeness of chromosomal information, procedure-to-result time interval and cost. RESULTS: Participants indicated a preference towards the karyotype test irrespective of cost and procedure-to-result time interval. The value of obtaining the extra information provided by karyotyping above that of rapid aneuploidy was pound267.82 (95% CI 226.71-323.31). Women would only accept the rapid aneuploidy test if results where available 18 days sooner than if they were undergoing a karyotyping test. Among women who traded between diagnostic tests, the value of extra chromosomal information was reduced to pound153.83 (95% CI 125.81-192.19). Women with high trait anxiety scores (>40) did not preferentially select one test. CONCLUSION: Chinese women showed a strong preference towards performing a full karyotype test and having a full chromosomal assessment performed for their pregnancy. Copyright (c) 2009 John Wiley & Sons, Ltd.
OBJECTIVE: To assess Chinese women's preference for the choice of a prenatal diagnosis test, karyotyping or rapid aneuploidy, and its relationship to maternal psychological state. STUDY DESIGN: Three hundred consenting women completed a self administered structured questionnaire which documented their psychological state and their preferred choice of diagnostic test for chromosomal abnormality using a discrete choice experiment design. Diagnostic tests were categorised according to three attributes: completeness of chromosomal information, procedure-to-result time interval and cost. RESULTS:Participants indicated a preference towards the karyotype test irrespective of cost and procedure-to-result time interval. The value of obtaining the extra information provided by karyotyping above that of rapid aneuploidy was pound267.82 (95% CI 226.71-323.31). Women would only accept the rapid aneuploidy test if results where available 18 days sooner than if they were undergoing a karyotyping test. Among women who traded between diagnostic tests, the value of extra chromosomal information was reduced to pound153.83 (95% CI 125.81-192.19). Women with high trait anxiety scores (>40) did not preferentially select one test. CONCLUSION: Chinese women showed a strong preference towards performing a full karyotype test and having a full chromosomal assessment performed for their pregnancy. Copyright (c) 2009 John Wiley & Sons, Ltd.
Authors: Antina de Jong; Wybo J Dondorp; Daniëlle R M Timmermans; Jan M M van Lith; Guido M W R de Wert Journal: Eur J Hum Genet Date: 2011-06-01 Impact factor: 4.246
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Authors: Yu-Hsiang Hsieh; Charlotte A Gaydos; M Terry Hogan; O Manuel Uy; Joany Jackman; Mary Jett-Goheen; Ariel Albertie; Derek T Dangerfield; Celia R Neustadt; Zachary S Wiener; Anne M Rompalo Journal: PLoS One Date: 2011-04-29 Impact factor: 3.240