PURPOSE: To determine clinical predictors and accuracy of (123)I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson's disease (PD). METHODS: Several clinical features and (123)I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (PDu) and 22 patients with PD without a previous history of antidopaminergic treatment (PDc) were retrospectively evaluated. RESULTS: DIP and PD shared all clinical features except symmetry of parkinsonian signs which was more frequently observed in patients with DIP (46.9%) than in patients with PDu (16.0%, p<0.05) or PDc (4.5%, p<0.01). Qualitatively (123)I-FP-CIT SPECT images were normal in 29 patients with DIP (90.6%) and abnormal in all patients with PD, and this imaging technique showed high levels of accuracy. CONCLUSION: DIP and PD are difficult to differentiate based on clinical signs. The precision of clinical diagnosis could be reliably enhanced by (123)I-FP-CIT SPECT imaging.
PURPOSE: To determine clinical predictors and accuracy of (123)I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson's disease (PD). METHODS: Several clinical features and (123)I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (PDu) and 22 patients with PD without a previous history of antidopaminergic treatment (PDc) were retrospectively evaluated. RESULTS:DIP and PD shared all clinical features except symmetry of parkinsonian signs which was more frequently observed in patients with DIP (46.9%) than in patients with PDu (16.0%, p<0.05) or PDc (4.5%, p<0.01). Qualitatively (123)I-FP-CIT SPECT images were normal in 29 patients with DIP (90.6%) and abnormal in all patients with PD, and this imaging technique showed high levels of accuracy. CONCLUSION:DIP and PD are difficult to differentiate based on clinical signs. The precision of clinical diagnosis could be reliably enhanced by (123)I-FP-CIT SPECT imaging.
Authors: S Hassin-Baer; P Sirota; A D Korczyn; T A Treves; B Epstein; H Shabtai; T Martin; Y Litvinjuk; N Giladi Journal: J Neural Transm (Vienna) Date: 2001 Impact factor: 3.575
Authors: Christoph Scherfler; Johannes Schwarz; Angelo Antonini; Donald Grosset; Francesc Valldeoriola; Kenneth Marek; Wolfgang Oertel; Eduardo Tolosa; Andrew J Lees; Werner Poewe Journal: Mov Disord Date: 2007-07-15 Impact factor: 10.338
Authors: Z Barrou; J Boddaert; V Faucounau; M O Habert; S Greffard; B Dieudonné; M Verny Journal: J Nutr Health Aging Date: 2014-01 Impact factor: 4.075
Authors: Françoise J Siepel; Arvid Rongve; Tirza C Buter; Mona K Beyer; Clive G Ballard; Jan Booij; Dag Aarsland Journal: BMJ Open Date: 2013-04-08 Impact factor: 2.692
Authors: Remco J J Knol; Jan C van den Bos; Anton G M Janssen; Kora de Bruin; Berthe L F van Eck-Smit; Jan Booij Journal: Int J Mol Imaging Date: 2011-06-13
Authors: Jose L López-Sendón Moreno; Araceli Alonso-Cánovas; Javier Buisán Catevilla; Nuria García Barragán; Iñigo Corral Corral; Alicia de Felipe Mimbrera; María Consuelo Matute Lozano; Jaime Masjuan Vallejo; Juan Carlos Martínez-Castrillo Journal: Mov Disord Clin Pract Date: 2015-12-18
Authors: Angela E P Bouwmans; Annemarie M M Vlaar; Werner H Mess; Alfons Kessels; Wim E J Weber Journal: BMJ Open Date: 2013-04-02 Impact factor: 2.692