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Literature DB >> 1986251

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

D Ginsberg¹, D Michael-Michalovitz, D Ginsberg¹, M Oren.

Abstract

A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5 degrees C. While much of the protein was cytoplasmic in cells proliferating at 37.5 degrees C, it became predominantly nuclear at 32.5 degrees C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.

Entities: Disease Gene

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Year: 1991 PMID： 1986251 PMCID： PMC359675 DOI： 10.1128/mcb.11.1.582-585.1991

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

24 in total

1. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.

Authors: P Hinds; C Finlay; A J Levine
Journal: J Virol Date: 1989-02 Impact factor: 5.103

2. Oligomerization of oncoprotein p53.

Authors: S Kraiss; A Quaiser; M Oren; M Montenarh
Journal: J Virol Date: 1988-12 Impact factor: 5.103

3. Meth A fibrosarcoma cells express two transforming mutant p53 species.

Authors: D Eliyahu; N Goldfinger; O Pinhasi-Kimhi; G Shaulsky; Y Skurnik; N Arai; V Rotter; M Oren
Journal: Oncogene Date: 1988-09 Impact factor: 9.867

4. Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

Authors: H W Stürzbecher; P Chumakov; W J Welch; J R Jenkins
Journal: Oncogene Date: 1987-05 Impact factor: 9.867

5. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

Authors: C A Finlay; P W Hinds; T H Tan; D Eliyahu; M Oren; A J Levine
Journal: Mol Cell Biol Date: 1988-02 Impact factor: 4.272

6. Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

Authors: H W Stürzbecher; C Addison; J R Jenkins
Journal: Mol Cell Biol Date: 1988-09 Impact factor: 4.272

7. Intermediate filament proteins in nonfilamentous structures: transient disintegration and inclusion of subunit proteins in granular aggregates.

Authors: W W Franke; E Schmid; C Grund; B Geiger
Journal: Cell Date: 1982-08 Impact factor: 41.582

8. Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells.

Authors: A Zantema; P I Schrier; A Davis-Olivier; T van Laar; R T Vaessen; A J van der EB
Journal: Mol Cell Biol Date: 1985-11 Impact factor: 4.272

9. p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

Authors: A Rogel; M Popliker; C G Webb; M Oren
Journal: Mol Cell Biol Date: 1985-10 Impact factor: 4.272

10. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

Authors: L F Parada; H Land; R A Weinberg; D Wolf; V Rotter
Journal: Nature Date: 1984 Dec 13-19 Impact factor: 49.962

40 in total

1. The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis.

Authors: B C McKay; F Chen; C R Perumalswami; F Zhang; M Ljungman
Journal: Mol Biol Cell Date: 2000-08 Impact factor: 4.138

2. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

Authors: E Shaulian; A Zauberman; D Ginsberg; M Oren
Journal: Mol Cell Biol Date: 1992-12 Impact factor: 4.272

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

1. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.

2. Oligomerization of oncoprotein p53.

3. Meth A fibrosarcoma cells express two transforming mutant p53 species.

4. Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

5. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

6. Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

7. Intermediate filament proteins in nonfilamentous structures: transient disintegration and inclusion of subunit proteins in granular aggregates.

8. Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells.

9. p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

10. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

1. The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis.

2. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

3. Repression of the basal c-fos promoter by wild-type p53.

4. Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells.

5. Expression of wild-type and mutant p53 proteins by recombinant vaccinia viruses.

Review 6. Stress-induced corneal epithelial apoptosis mediated by K+ channel activation.

7. A DNA binding domain is contained in the C-terminus of wild type p53 protein.

8. p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells.

9. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis.

10. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.