Literature DB >> 19861446

Enhancing cancer vaccine efficacy via modulation of the tumor microenvironment.

Mary L Disis1.   

Abstract

The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are "self," therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGFbeta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGFbeta will enhance vaccine efficacy.

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Year:  2009        PMID： 19861446     DOI： 10.1158/1078-0432.CCR-09-2256

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  6 in total

Review 1.  Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.

Authors:  Akshata Udyavar; Terrence L Geiger
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2010-08-01       Impact factor: 4.291

2.  Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity.

Authors:  Zuqiang Liu; Xingxing Hao; Yi Zhang; Jiying Zhang; Cara D Carey; Louis D Falo; Walter J Storkus; Zhaoyang You
Journal:  Oncoimmunology       Date:  2017-04-24       Impact factor: 8.110

3.  Immune regulation of cancer.

Authors:  Mary L Disis
Journal:  J Clin Oncol       Date:  2010-06-01       Impact factor: 44.544

4.  Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions.

Authors:  Hongjie Wang; ZongYi Li; Roma Yumul; Stephanie Lara; Akseli Hemminki; Pascal Fender; André Lieber
Journal:  J Virol       Date:  2011-04-27       Impact factor: 5.103

5.  Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

Authors:  Max Yan; Nicholas Jene; David Byrne; Ewan K A Millar; Sandra A O'Toole; Catriona M McNeil; Gaynor J Bates; Adrian L Harris; Alison H Banham; Robert L Sutherland; Stephen B Fox
Journal:  Breast Cancer Res       Date:  2011-04-26       Impact factor: 6.466

Review 6.  Targeting TGFβ signal transduction for cancer therapy.

Authors:  Sijia Liu; Jiang Ren; Peter Ten Dijke
Journal:  Signal Transduct Target Ther       Date:  2021-01-08
  6 in total

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