| Literature DB >> 19861117 |
Antonella Cormio1, Flora Guerra, Gennaro Cormio, Vito Pesce, Flavio Fracasso, Vera Loizzi, Palmiro Cantatore, Luigi Selvaggi, Maria Nicola Gadaleta.
Abstract
PGC-1alpha-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the citrate synthase activity, the mitochondrial DNA content and the TFAM level were found doubled compared to control endometrial tissue. Moreover, a 1.6- and 1.8-fold increase, respectively, of NRF-1 and PGG-1alpha expression was found. This study demonstrates, for the first time, that the increased mitochondrial biogenesis in type I endometrial cancer is associated to the upregulation of PGC-1alpha signalling pathway.Entities:
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Year: 2009 PMID： 19861117 DOI： 10.1016/j.bbrc.2009.10.114
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575