BACKGROUND: We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms. METHODS: An alcohol dependence symptom score, based on DSM-IIIR and DSM-IV criteria, was examined. Twins and their nontwin siblings (1,654 males, 2,518 females), aged 21 to 81 years, were interviewed, with 803 individuals interviewed on 2 occasions, approximately 10 years apart. Linkage analyses were conducted on datasets compiled to maximize data collected at either the younger or the older age. In addition, linkage was compared between full samples and truncated samples that excluded the lightest drinkers (approximately 10% of the sample). RESULTS: Suggestive peaks on chromosome 5p (LODs >2.2) were found in a region previously identified in alcohol linkage studies using clinical populations. Linkage signal strength was found to vary between full and truncated samples and when samples differed only on the collection age for a sample subset. CONCLUSIONS: The results support the finding that large community samples can be informative in the study of alcohol-related traits.
BACKGROUND: We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms. METHODS: An alcohol dependence symptom score, based on DSM-IIIR and DSM-IV criteria, was examined. Twins and their nontwin siblings (1,654 males, 2,518 females), aged 21 to 81 years, were interviewed, with 803 individuals interviewed on 2 occasions, approximately 10 years apart. Linkage analyses were conducted on datasets compiled to maximize data collected at either the younger or the older age. In addition, linkage was compared between full samples and truncated samples that excluded the lightest drinkers (approximately 10% of the sample). RESULTS: Suggestive peaks on chromosome 5p (LODs >2.2) were found in a region previously identified in alcohol linkage studies using clinical populations. Linkage signal strength was found to vary between full and truncated samples and when samples differed only on the collection age for a sample subset. CONCLUSIONS: The results support the finding that large community samples can be informative in the study of alcohol-related traits.
Authors: Arpana Agrawal; Anthony L Hinrichs; Gerald Dunn; Sarah Bertelsen; Danielle M Dick; Scott F Saccone; Nancy L Saccone; Richard A Grucza; Jen C Wang; C Robert Cloninger; Howard J Edenberg; Tatiana Foroud; Victor Hesselbrock; John Kramer; Kathleen K Bucholz; Samuel Kuperman; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Alison M Goate; Laura J Bierut Journal: Drug Alcohol Depend Date: 2007-10-17 Impact factor: 4.492
Authors: Howard J Edenberg; Danielle M Dick; Xiaoling Xuei; Huijun Tian; Laura Almasy; Lance O Bauer; Raymond R Crowe; Alison Goate; Victor Hesselbrock; Kevin Jones; Jennifer Kwon; Ting-Kai Li; John I Nurnberger; Sean J O'Connor; Theodore Reich; John Rice; Marc A Schuckit; Bernice Porjesz; Tatiana Foroud; Henri Begleiter Journal: Am J Hum Genet Date: 2004-03-12 Impact factor: 11.025
Authors: Danielle M Dick; John Nurnberger; Howard J Edenberg; Alison Goate; Ray Crowe; John Rice; Kathleen K Bucholz; John Kramer; Marc A Schuckit; Tom L Smith; Bernice Porjesz; Henri Begleiter; Victor Hesselbrock; Tatiana Foroud Journal: Alcohol Clin Exp Res Date: 2002-10 Impact factor: 3.455
Authors: D M Dick; T-K Li; H J Edenberg; V Hesselbrock; J Kramer; S Kuperman; B Porjesz; K Bucholz; A Goate; J Nurnberger; T Foroud Journal: Mol Psychiatry Date: 2004-01 Impact factor: 15.992
Authors: Shizhong Han; Bao-Zhu Yang; Henry R Kranzler; Xiaoming Liu; Hongyu Zhao; Lindsay A Farrer; Eric Boerwinkle; James B Potash; Joel Gelernter Journal: Am J Hum Genet Date: 2013-11-21 Impact factor: 11.025