Mathematical modeling and the epidemiological research process.

The authors of this paper advocate for the expanded use of mathematical models in epidemiology and provide an overview of the principles of mathematical modeling. Mathematical models can be used throughout the epidemiological research process. Initially they may help to refine study questions by visually expressing complex systems, directing literature searches, and identifying sensitive variables. In the study design phase, models can be used to test sampling strategies, to estimate sample size and power, and to predict outcomes for studies impractical due to time or ethical considerations. Once data are collected, models can assist in the interpretation of results, the exploration of causal pathways, and the combined analysis of data from multiple sources. Finally, models are commonly used in the process of applying research findings to public health practice by estimating population risk, predicting the effects of interventions, and contributing to the evaluation of ongoing programs. Mathematical modeling has the potential to make significant contributions to the field of epidemiology by enhancing the research process, serving as a tool for communicating findings to policymakers, and fostering interdisciplinary collaboration.