Literature DB >> 19859726

A novel and an effective analytical approach for the LC-MS determination of ethyl glucuronide and ethyl sulfate in urine.

Donata Favretto1, Alessandro Nalesso, Giampietro Frison, Guido Viel, Pietro Traldi, Santo Davide Ferrara.   

Abstract

An alternative liquid chromatography-mass spectrometry (LC-MS) method based on no discharge (ND) atmospheric pressure chemical ionization (APCI) was developed for the simultaneous determination of ethyl glucuronide (EtG) and ethyl sulfate (EtS) in urine in negative ion conditions. Abundant [M-H](-) species of EtG and EtS were obtained, allowing to reach limits of quantification (0.1 microg/ml for both analytes), accuracy, and precision comparable to those proposed in the literature. Additionally, the LC-ND-APCI-MS method proved to be reliable, requiring little maintenance even when high throughput analyses (i.e., 6,000 samples per year) were required.

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Year:  2009        PMID： 19859726     DOI： 10.1007/s00414-009-0376-1

Source DB:  PubMed          Journal:  Int J Legal Med        ISSN： 0937-9827            Impact factor:   2.686


  18 in total

1.  Synthesis and characterization of ethyl sulfate and D5-ethyl sulfate as reference substances for applications in clinical and forensic toxicology.

Authors:  Alessandro Nalesso; Giampietro Frison; Donata Favretto; Sergio Maietti; Santo Davide Ferrara
Journal:  Rapid Commun Mass Spectrom       Date:  2005       Impact factor: 2.419

2.  No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices.

Authors:  Sherri B Turnipseed; Wendy C Andersen; Christine M Karbiwnyk; José E Roybal; Keith E Miller
Journal:  Rapid Commun Mass Spectrom       Date:  2006       Impact factor: 2.419

3.  A predictive model for matrix and analyte effects in electrospray ionization of singly-charged ionic analytes.

Authors:  C G Enke
Journal:  Anal Chem       Date:  1997-12-01       Impact factor: 6.986

4.  Analysis of ethyl glucuronide in human serum by capillary electrophoresis with sample self-stacking and indirect detection.

Authors:  L Krivánková; J Caslavska; H Malásková; P Gebauer; W Thormann
Journal:  J Chromatogr A       Date:  2005-07-15       Impact factor: 4.759

5.  Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid chromatography-tandem mass spectrometry.

Authors:  Wolfgang Bicker; Michael Lämmerhofer; Thomas Keller; Rainer Schuhmacher; Rudolf Krska; Wolfgang Lindner
Journal:  Anal Chem       Date:  2006-08-15       Impact factor: 6.986

6.  Ethyl glucuronide--a marker of alcohol consumption and a relapse marker with clinical and forensic implications.

Authors:  F M Wurst; C Kempter; S Seidl; A Alt
Journal:  Alcohol Alcohol       Date:  1999 Jan-Feb       Impact factor: 2.826

7.  Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption.

Authors:  Friedrich Martin Wurst; Sebastian Dresen; John P Allen; Gerhard Wiesbeck; Marc Graf; Wolfgang Weinmann
Journal:  Addiction       Date:  2006-02       Impact factor: 6.526

8.  Determination of ethyl glucuronide in human serum by hyphenation of capillary isotachophoresis and zone electrophoresis.

Authors:  Michaela Nováková; Ludmila Krivánková
Journal:  Electrophoresis       Date:  2008-04       Impact factor: 3.535

9.  Confirmatory analysis of ethylglucuronide in urine by liquid-chromatography/electrospray ionization/tandem mass spectrometry according to forensic guidelines.

Authors:  Wolfgang Weinmann; Patrick Schaefer; Annette Thierauf; André Schreiber; Friedrich Martin Wurst
Journal:  J Am Soc Mass Spectrom       Date:  2004-02       Impact factor: 3.109

10.  An improved method to detect ethyl glucuronide in urine using reversed-phase liquid chromatography and pulsed electrochemical detection.

Authors:  Romina Shah; William R Lacourse
Journal:  Anal Chim Acta       Date:  2006-06-16       Impact factor: 6.558
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  3 in total

1.  A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethyl glucuronide and ethyl sulfate in urine validated according to forensic guidelines.

Authors:  M E Albermann; F Musshoff; B Madea
Journal:  J Chromatogr Sci       Date:  2012-01       Impact factor: 1.618

Review 2.  Ethyl glucuronide concentration in hair for detecting heavy drinking and/or abstinence: a meta-analysis.

Authors:  Rafael Boscolo-Berto; Guido Viel; Massimo Montisci; Claudio Terranova; Donata Favretto; Santo Davide Ferrara
Journal:  Int J Legal Med       Date:  2012-12-19       Impact factor: 2.686

Review 3.  Phosphatidylethanol in blood as a marker of chronic alcohol use: a systematic review and meta-analysis.

Authors:  Guido Viel; Rafael Boscolo-Berto; Giovanni Cecchetto; Paolo Fais; Alessandro Nalesso; Santo Davide Ferrara
Journal:  Int J Mol Sci       Date:  2012-11-13       Impact factor: 5.923
  3 in total

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