OBJECTIVE: Surgery for hilar cholangiocarcinoma (HCCA) remains challenging, with radical procedures thought to offer the best chance of long-term survival. Here we present our data for surgical resection of HCCA for the period 2001-2008. METHODS: A prospectively maintained database was interrogated to identify all resections. Clinico-pathological data were analyzed and assessed for impact on survival. RESULTS: 51 patients were identified. Almost three-quarters required hepatic trisectionectomy. Overall survival was 76% at 1 year, 36% at 3 years and 20% at 5 years. When R0 resection was achieved, the 5-year survival was 40%. Portal vein resection, perineural invasion and T-stage were predictive of overall survival on univariate analysis. Only T-stage remained significant on multivariate analysis. Lymph node status predicted disease-free survival. CONCLUSION: Radical surgery continues to offer the prospect of long-term survival for patients with HCCA. Earlier detection and referral to tertiary centers may allow more patients to have potentially curative surgical resections.
OBJECTIVE: Surgery for hilar cholangiocarcinoma (HCCA) remains challenging, with radical procedures thought to offer the best chance of long-term survival. Here we present our data for surgical resection of HCCA for the period 2001-2008. METHODS: A prospectively maintained database was interrogated to identify all resections. Clinico-pathological data were analyzed and assessed for impact on survival. RESULTS: 51 patients were identified. Almost three-quarters required hepatic trisectionectomy. Overall survival was 76% at 1 year, 36% at 3 years and 20% at 5 years. When R0 resection was achieved, the 5-year survival was 40%. Portal vein resection, perineural invasion and T-stage were predictive of overall survival on univariate analysis. Only T-stage remained significant on multivariate analysis. Lymph node status predicted disease-free survival. CONCLUSION: Radical surgery continues to offer the prospect of long-term survival for patients with HCCA. Earlier detection and referral to tertiary centers may allow more patients to have potentially curative surgical resections.
Authors: Sameer H Patel; David A Kooby; Charles A Staley; Juan M Sarmiento; Shishir K Maithel Journal: HPB (Oxford) Date: 2011-07-26 Impact factor: 3.647
Authors: Jamie E Anderson; Alan W Hemming; David C Chang; Mark A Talamini; Kristin L Mekeel Journal: J Gastrointest Surg Date: 2012-07-31 Impact factor: 3.452
Authors: Kai Mao; Jieqiong Liu; Jian Sun; Jianlong Zhang; Jie Chen; Timothy M Pawlik; Lisa K Jacobs; Zhiyu Xiao; Jie Wang Journal: J Gastroenterol Hepatol Date: 2016-02 Impact factor: 4.029