Literature DB >> 19857966

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

Stephanos Ioannidis1, Michelle L Lamb, Audrey M Davies, Lynsie Almeida, Mei Su, Geraldine Bebernitz, Minwei Ye, Kirsten Bell, Marat Alimzhanov, Michael Zinda.   

Abstract

The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.

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Year:  2009        PMID: 19857966     DOI: 10.1016/j.bmcl.2009.10.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

1.  Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.

Authors:  Maninder Kaur; Pankaj Kumar Singh; Manjinder Singh; Renu Bahadur; Om Silakari
Journal:  Mol Divers       Date:  2017-11-14       Impact factor: 2.943

Review 2.  The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors.

Authors:  R Baskin; A Majumder; P P Sayeski
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530

3.  Palladium-catalyzed amination of unprotected five-membered heterocyclic bromides.

Authors:  Mingjuan Su; Naoyuki Hoshiya; Stephen L Buchwald
Journal:  Org Lett       Date:  2014-01-13       Impact factor: 6.005

Review 4.  Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway.

Authors:  Charles J Malemud
Journal:  Pharmaceuticals (Basel)       Date:  2010-05-12

5.  Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases.

Authors:  Kamonpan Sanachai; Panupong Mahalapbutr; Kowit Hengphasatporn; Yasuteru Shigeta; Supaphorn Seetaha; Lueacha Tabtimmai; Thierry Langer; Peter Wolschann; Tanakorn Kittikool; Sirilata Yotphan; Kiattawee Choowongkomon; Thanyada Rungrotmongkol
Journal:  ACS Omega       Date:  2022-09-06
  5 in total

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