Literature DB >> 1985792

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

H Gunji1, S Kharbanda, D Kufe.   

Abstract

The present results demonstrate that treatment of human U-937 myeloid leukemia cells with 1-beta-D-arabinofuranosylcytosine (ara-C) is associated with DNA fragmentation at multiples of approximately 200 base pairs. The extent of ara-C-induced DNA fragmentation was dependent on drug concentration and time of exposure. This pattern of internucleosomal DNA cleavage has been observed during programmed cell death and was associated in the present studies with loss of clonogenic survival. The results also demonstrate that the c-jun protooncogene is induced by ara-C during periods of DNA cleavage. These findings suggest that ara-C activates a program involving both oligonucleosomal DNA fragmentation and changes in early response gene expression.

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Year:  1991        PMID： 1985792

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  21 in total

Review 1.  Apoptosis induced by anticancer drugs.

Authors:  J A Hickman
Journal:  Cancer Metastasis Rev       Date:  1992-09       Impact factor: 9.264

2.  Mechanistic implications of alterations in HL-60 cell nascent DNA after exposure to 1-beta-D-arabinofuranosylcytosine.

Authors:  D D Ross; D P Cuddy; N Cohen; D R Hensley
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

3.  Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

Authors:  A Benito; D Grillot; G Nuñez; J L Fernández-Luna
Journal:  Am J Pathol       Date:  1995-02       Impact factor: 4.307

Review 4.  A potential role for apoptosis in neurodegeneration and Alzheimer's disease.

Authors:  C W Cotman; A J Anderson
Journal:  Mol Neurobiol       Date:  1995-02       Impact factor: 5.590

5.  Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.

Authors:  Caroline Palmeira dos Santos; Gustavo J S Pereira; Christiano M V Barbosa; Aron Jurkiewicz; Soraya S Smaili; Claudia Bincoletto
Journal:  J Cancer Res Clin Oncol       Date:  2014-06       Impact factor: 4.553

6.  Role of Ca2+ in the intracellular signaling pathway of anti-IgM-induced apoptosis in the human B-cell line, MBC-1, established from Burkitt lymphoma.

Authors:  Masamune Higashigawa; Yoshihiro Komada
Journal:  Int J Hematol       Date:  2002-07       Impact factor: 2.490

7.  Biological effects of a relatively low concentration of 1-beta-D-arabinofuranosylcytosine in K562 cells: alterations of the cell cycle, erythroid-differentiation, and apoptosis.

Authors:  H Yamada; J Horiguchi-Yamada; M Nagai; S Takahara; T Sekikawa; T Kawano; K Itoh; S Fukumi; S Iwase
Journal:  Mol Cell Biochem       Date:  1998-10       Impact factor: 3.396

8.  1-beta-D-arabinofuranosylcytosine-, mitoxantrone-, and paclitaxel-induced apoptosis in HL-60 cells: improved method for detection of internucleosomal DNA fragmentation.

Authors:  S Ray; V Ponnathpur; Y Huang; C Tang; M E Mahoney; A M Ibrado; G Bullock; K Bhalla
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

Review 9.  New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase.

Authors:  V W Ruiz van Haperen; G J Peters
Journal:  Pharm World Sci       Date:  1994-04-15

10.  Adozelesin, a potent new alkylating agent: cell-killing kinetics and cell-cycle effects.

Authors:  B K Bhuyan; K S Smith; E G Adams; T L Wallace; D D Von Hoff; L H Li
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333
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