| Literature DB >> 19857594 |
Erwin Lamping1, Philippe V Baret, Ann R Holmes, Brian C Monk, Andre Goffeau, Richard D Cannon.
Abstract
The overexpression of pleiotropic drug resistance (PDR) efflux pumps of the ATP-binding cassette (ABC) transporter superfamily frequently correlates with multidrug resistance. Phylogenetic analysis of 349 full-size ( approximately 160kDa) PDR proteins (Pdrps) from 55 fungal species, including major fungal pathogens, identified nine separate protein clusters (A-G, H1a/H1b and H2). Fungal, plant and human ABCG-family Pdrps possess a nucleotide-binding domain [NBD] and a transmembrane domain [TMD] in a family-defining 'reverse' ABC transporter topology [NBD-TMD] that is duplicated [NBD-TMD](2) in full-size fungal and plant Pdrps. Although full-size Pdrps have similar halves indicating early gene duplication/fusion, they show asymmetry of their NBDs and extracellular loops (ELs). Members of cluster F are most symmetric and may be closely related to the evolutionary ancestor of Pdrps. Unique structural elements are predicted, new PDR-specific motifs identified, and the significance of these and other structural features discussed. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19857594 PMCID： PMC2814995 DOI： 10.1016/j.fgb.2009.10.007
Source DB: PubMed Journal: Fungal Genet Biol ISSN： 1087-1845 Impact factor: 3.495