| Literature DB >> 19857464 |
Sead Chadi1, Laurine Buscara, Christine Pechoux, José Costa, Johann Laubier, Marie-Christine Chaboissier, Eric Pailhoux, Jean-Luc Vilotte, Eric Chanat, Fabienne Le Provost.
Abstract
The R-spondin (Rspo) proteins constitute a novel class of ligands that induce Wnt signalling. Rspo1 knockout XX mice were previously shown to be sex-reversed, but some remain sub-fertile. These last were unable to feed their pups for some unknown reason. Using these mice and transplanted mammary tissues from Rspo1(-/-) virgin mice in nude mice, we report that the lack of Rspo1 expression results in the absence of duct side-branching development and subsequent alveolar formation, explaining the above mentioned phenotype. Our data demonstrate that local epithelial Rspo1 signalling is required for normal development of the mammary gland.Entities:
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Year: 2009 PMID： 19857464 DOI： 10.1016/j.bbrc.2009.10.104
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575