Literature DB >> 19855013

The regulation of TGFbeta signal transduction.

Aristidis Moustakas1, Carl-Henrik Heldin.   

Abstract

Transforming growth factor beta (TGFbeta) pathways are implicated in metazoan development, adult homeostasis and disease. TGFbeta ligands signal via receptor serine/threonine kinases that phosphorylate, and activate, intracellular Smad effectors as well as other signaling proteins. Oligomeric Smad complexes associate with chromatin and regulate transcription, defining the biological response of a cell to TGFbeta family members. Signaling is modulated by negative-feedback regulation via inhibitory Smads. We review here the mechanisms of TGFbeta signal transduction in metazoans and emphasize events crucial for embryonic development.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19855013     DOI： 10.1242/dev.030338

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  372 in total

1.  Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.

Authors:  Sunyong Tang; Paige Snider; Antony B Firulli; Simon J Conway
Journal:  Dev Biol       Date:  2010-05-08       Impact factor: 3.582

2.  Loss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1.

Authors:  Yuan Liu; Marty W Mayo; Aizhen Xiao; Emily H Hall; Elianna B Amin; Kyuichi Kadota; Prasad S Adusumilli; David R Jones
Journal:  Mol Cell Biol       Date:  2014-11-03       Impact factor: 4.272

Review 3.  TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.

Authors:  Rohan Samarakoon; Jessica M Overstreet; Stephen P Higgins; Paul J Higgins
Journal:  Cell Tissue Res       Date:  2011-06-04       Impact factor: 5.249

4.  The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.

Authors:  Chenxi Tian; Debjeet Sen; Herong Shi; Marisa L Foehr; Yevgeniy Plavskin; Olena K Vatamaniuk; Jun Liu
Journal:  Development       Date:  2010-06-09       Impact factor: 6.868

5.  MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells.

Authors:  Yingjie Yu; Shailender S Kanwar; Bhaumik B Patel; Phil-Sun Oh; Jyoti Nautiyal; Fazlul H Sarkar; Adhip P N Majumdar
Journal:  Carcinogenesis       Date:  2011-11-09       Impact factor: 4.944

6.  Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.

Authors:  Brandoch D Cook; Susanna Liu; Todd Evans
Journal:  Blood       Date:  2011-04-22       Impact factor: 22.113

7.  The regulatory protein SnoN antagonizes activin/Smad2 protein signaling and thereby promotes adipocyte differentiation and obesity in mice.

Authors:  Qingwei Zhu; Amanda Chang; Albert Xu; Kunxin Luo
Journal:  J Biol Chem       Date:  2018-07-20       Impact factor: 5.157

8.  TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression.

Authors:  Soumya Maity; Falguni Das; Balakuntalam S Kasinath; Nandini Ghosh-Choudhury; Goutam Ghosh Choudhury
Journal:  J Biol Chem       Date:  2020-07-30       Impact factor: 5.157

9.  Podocyte and endothelial-specific elimination of BAMBI identifies differential transforming growth factor-β pathways contributing to diabetic glomerulopathy.

Authors:  Han Lai; Anqun Chen; Hong Cai; Jia Fu; Fadi Salem; Yu Li; John C He; Detlef Schlondorff; Kyung Lee
Journal:  Kidney Int       Date:  2020-04-26       Impact factor: 10.612

10.  microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression.

Authors:  Soumya Maity; Amit Bera; Nandini Ghosh-Choudhury; Falguni Das; Balakuntalam S Kasinath; Goutam Ghosh Choudhury
Journal:  Exp Cell Res       Date:  2018-02-01       Impact factor: 3.905
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.