CONTEXT: Hypothermia improves neurological outcome for comatose survivors of out-of-hospital cardiac arrest. Use of computer controlled high surface area devices for cooling may lead to faster cooling rates and potentially improve patient outcome. OBJECTIVE: To compare the effectiveness of surface cooling with the standard blankets and ice packs to the Arctic Sun, a mechanical device used for temperature management. DESIGN, SETTING, AND PATIENTS: Multi-center randomized trial of hemodynamically stable comatose survivors of out-of-hospital cardiac arrest. INTERVENTION: Standard post-resuscitative care inducing hypothermia using cooling blankets and ice (n=30) or the Arctic Sun (n=34). MAIN OUTCOME MEASURES: The primary end point was the proportion of subjects who reached a target temperature within 4h of beginning cooling. The secondary end points were time interval to achieve target temperature (34 degrees C) and survival to 3 months. RESULTS: The proportion of subjects cooled below the 34 degrees C target at 4h was 71% for the Arctic Sun group and 50% for the standard cooling group (p=0.12). The median time to target was 54 min faster for cooled patients in the Arctic Sun group than the standard cooling group (p<0.01). Survival rates with good neurological outcome were similar; 46% of Arctic Sun patients and 38% of standard patients had a cerebral performance category of 1 or 2 at 30 days (p=0.6). CONCLUSIONS: While the proportion of subjects reaching target temperature within 4h was not significantly different, the Arctic Sun cooled patients to a temperature of 34 degrees C more rapidly than standard cooling blankets. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
RCT Entities:
CONTEXT: Hypothermia improves neurological outcome for comatose survivors of out-of-hospital cardiac arrest. Use of computer controlled high surface area devices for cooling may lead to faster cooling rates and potentially improve patient outcome. OBJECTIVE: To compare the effectiveness of surface cooling with the standard blankets and ice packs to the Arctic Sun, a mechanical device used for temperature management. DESIGN, SETTING, AND PATIENTS: Multi-center randomized trial of hemodynamically stable comatose survivors of out-of-hospital cardiac arrest. INTERVENTION: Standard post-resuscitative care inducing hypothermia using cooling blankets and ice (n=30) or the Arctic Sun (n=34). MAIN OUTCOME MEASURES: The primary end point was the proportion of subjects who reached a target temperature within 4h of beginning cooling. The secondary end points were time interval to achieve target temperature (34 degrees C) and survival to 3 months. RESULTS: The proportion of subjects cooled below the 34 degrees C target at 4h was 71% for the Arctic Sun group and 50% for the standard cooling group (p=0.12). The median time to target was 54 min faster for cooled patients in the Arctic Sun group than the standard cooling group (p<0.01). Survival rates with good neurological outcome were similar; 46% of Arctic Sun patients and 38% of standard patients had a cerebral performance category of 1 or 2 at 30 days (p=0.6). CONCLUSIONS: While the proportion of subjects reaching target temperature within 4h was not significantly different, the Arctic Sun cooled patients to a temperature of 34 degrees C more rapidly than standard cooling blankets. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: Benjamin S Abella; James W Rhee; Kuang-Ning Huang; Terry L Vanden Hoek; Lance B Becker Journal: Resuscitation Date: 2005-02 Impact factor: 5.262
Authors: Ala Nozari; Peter Safar; S William Stezoski; Xianren Wu; Scott Kostelnik; Ann Radovsky; Samuel Tisherman; Patrick M Kochanek Journal: Circulation Date: 2006-06-13 Impact factor: 29.690
Authors: Turner S Baker; Adantchede L Zannou; Danna Cruz; Niranjan Khadka; Christopher Kellner; Richard Tyc; Marom Bikson; Anthony Costa Journal: IEEE Trans Neural Syst Rehabil Eng Date: 2022-08-11 Impact factor: 4.528
Authors: Romergryko G Geocadin; Matthew A Koenig; Xiaofeng Jia; Robert D Stevens; Mary Ann Peberdy Journal: Neurol Clin Date: 2008-05 Impact factor: 3.806
Authors: Mun Hee Choi; Young Eun Gil; Seong-Joon Lee; Jin Soo Lee; Jeong-Ho Hong; Sung-Il Sohn; Yong-Won Kim; Yang-Ha Hwang; Ji Man Hong Journal: Neurocrit Care Date: 2020-08-18 Impact factor: 3.210
Authors: Alicia M Alcamo; Rebecca Lavezoli; Cameron Dezfulian; Dennis W Simon; Rajesh K Aneja; Robert S B Clark; Patrick M Kochanek; Ericka L Fink Journal: Ther Hypothermia Temp Manag Date: 2020-05-19 Impact factor: 1.286