Literature DB >> 19854210

The capsule drug device: novel approach for drug delivery to the eye.

Sarah A Molokhia1, Himanshu Sant, Jacquelyn Simonis, C J Bishop, R M Burr, Bruce K Gale, Balamurali K Ambati.   

Abstract

Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semi-permeable membrane for controlled delivery and silicone check valves for refilling. The device showed near zero-order release kinetics and Avastin stability was investigated with accelerated temperature studies. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19854210     DOI： 10.1016/j.visres.2009.10.013

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  13 in total

Review 1.  Single compartment drug delivery.

Authors:  Michael J Cima; Heejin Lee; Karen Daniel; Laura M Tanenbaum; Aikaterini Mantzavinou; Kevin C Spencer; Qunya Ong; Jay C Sy; John Santini; Carl M Schoellhammer; Daniel Blankschtein; Robert S Langer
Journal:  J Control Release       Date:  2014-05-04       Impact factor: 9.776

2.  A flexible device for ocular iontophoretic drug delivery.

Authors:  Yushi Zhang; Yao Chen; Xiaoxue Yu; Yangjia Qi; Yufeng Chen; Yuxi Liu; Yuntao Hu; Zhihong Li
Journal:  Biomicrofluidics       Date:  2016-02-24       Impact factor: 2.800

3.  Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis.

Authors:  S Kevin Li; Mark R Liddell; He Wen
Journal:  J Pharm Biomed Anal       Date:  2011-01-05       Impact factor: 3.935

Review 4.  Reservoir-based drug delivery systems utilizing microtechnology.

Authors:  Cynthia L Stevenson; John T Santini; Robert Langer
Journal:  Adv Drug Deliv Rev       Date:  2012-02-21       Impact factor: 15.470

Review 5.  Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.

Authors:  Nupura S Bhise; Ron B Shmueli; Joel C Sunshine; Stephany Y Tzeng; Jordan J Green
Journal:  Expert Opin Drug Deliv       Date:  2011-02-22       Impact factor: 6.648

Review 6.  In vitro dissolution testing models of ocular implants for posterior segment drug delivery.

Authors:  Muhammad Faris Adrianto; Febri Annuryanti; Clive G Wilson; Ravi Sheshala; Raghu Raj Singh Thakur
Journal:  Drug Deliv Transl Res       Date:  2021-08-11       Impact factor: 5.671

7.  Preparation of a novel floating ring capsule-type dosage form for stomach specific delivery.

Authors:  Md Ismail Mouzam; M H G Dehghan; Shaikh Asif; Trupti Sahuji; Pooja Chudiwal
Journal:  Saudi Pharm J       Date:  2011-01-18       Impact factor: 4.330

Review 8.  Fouling in ocular devices: implications for drug delivery, bioactive surface immobilization, and biomaterial design.

Authors:  Onyinye J Uwaezuoke; Pradeep Kumar; Viness Pillay; Yahya E Choonara
Journal:  Drug Deliv Transl Res       Date:  2021-01-16       Impact factor: 4.617

Review 9.  Polymeric Implants for the Treatment of Intraocular Eye Diseases: Trends in Biodegradable and Non-Biodegradable Materials.

Authors:  Paulina García-Estrada; Miguel A García-Bon; Edgar J López-Naranjo; Dulce N Basaldúa-Pérez; Arturo Santos; Jose Navarro-Partida
Journal:  Pharmaceutics       Date:  2021-05-12       Impact factor: 6.321

10.  Design of an implantable device for ocular drug delivery.

Authors:  Jae-Hwan Lee; Ramana M Pidaparti; Gary M Atkinson; Ramana S Moorthy
Journal:  J Drug Deliv       Date:  2012-07-18
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.