Literature DB >> 19854183

Systems biology of lipid metabolism: from yeast to human.

Jens Nielsen1.   

Abstract

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated.

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Year:  2009        PMID： 19854183     DOI： 10.1016/j.febslet.2009.10.054

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  36 in total

1.  The stearoyl-coenzyme A desaturase 1 is essential for virulence and membrane stress in Candida parapsilosis through unsaturated fatty acid production.

Authors:  Long Nam Nguyen; Attila Gacser; Joshua D Nosanchuk
Journal:  Infect Immun       Date:  2010-10-25       Impact factor: 3.441

Review 2.  Omega-3 fatty acids, membrane remodeling and cancer prevention.

Authors:  Natividad R Fuentes; Eunjoo Kim; Yang-Yi Fan; Robert S Chapkin
Journal:  Mol Aspects Med       Date:  2018-04-12

3.  Many InChIs and quite some feat.

Authors:  Wendy A Warr
Journal:  J Comput Aided Mol Des       Date:  2015-06-17       Impact factor: 3.686

Review 4.  An overview of bioinformatics methods for modeling biological pathways in yeast.

Authors:  Jie Hou; Lipi Acharya; Dongxiao Zhu; Jianlin Cheng
Journal:  Brief Funct Genomics       Date:  2015-10-17       Impact factor: 4.241

5.  Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast.

Authors:  Pramote Chumnanpuen; Jie Zhang; Intawat Nookaew; Jens Nielsen
Journal:  Mol Genet Genomics       Date:  2012-05-24       Impact factor: 3.291

6.  Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis.

Authors:  Zsuzsanna Grózer; Adél Tóth; Renáta Tóth; Anita Kecskeméti; Csaba Vágvölgyi; Joshua D Nosanchuk; András Szekeres; Attila Gácser
Journal:  Virulence       Date:  2015       Impact factor: 5.882

7.  Splice isoform and pharmacological studies reveal that sterol depletion relocalizes α-synuclein and enhances its toxicity.

Authors:  Julie S Valastyan; Daniel J Termine; Susan Lindquist
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-10       Impact factor: 11.205

8.  Mapping condition-dependent regulation of lipid metabolism in Saccharomyces cerevisiae.

Authors:  Michael C Jewett; Christopher T Workman; Intawat Nookaew; Francisco A Pizarro; Eduardo Agosin; Lars I Hellgren; Jens Nielsen
Journal:  G3 (Bethesda)       Date:  2013-11-06       Impact factor: 3.154

9.  Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Authors:  Saranna Fanning; Aftabul Haque; Thibaut Imberdis; Valeriya Baru; M Inmaculada Barrasa; Silke Nuber; Daniel Termine; Nagendran Ramalingam; Gary P H Ho; Tallie Noble; Jackson Sandoe; Yali Lou; Dirk Landgraf; Yelena Freyzon; Gregory Newby; Frank Soldner; Elizabeth Terry-Kantor; Tae-Eun Kim; Harald F Hofbauer; Michel Becuwe; Rudolf Jaenisch; David Pincus; Clary B Clish; Tobias C Walther; Robert V Farese; Supriya Srinivasan; Michael A Welte; Sepp D Kohlwein; Ulf Dettmer; Susan Lindquist; Dennis Selkoe
Journal:  Mol Cell       Date:  2018-12-04       Impact factor: 17.970

Review 10.  Interpreting the lipidome: bioinformatic approaches to embrace the complexity.

Authors:  Jennifer E Kyle; Lucila Aimo; Alan J Bridge; Geremy Clair; Maria Fedorova; J Bernd Helms; Martijn R Molenaar; Zhixu Ni; Matej Orešič; Denise Slenter; Egon Willighagen; Bobbie-Jo M Webb-Robertson
Journal:  Metabolomics       Date:  2021-06-06       Impact factor: 4.290
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