| Literature DB >> 19854048 |
N Yi Mok1, James Chadwick, Katherine A B Kellett, Nigel M Hooper, A Peter Johnson, Colin W G Fishwick.
Abstract
A novel series of isatin-based inhibitors of beta-secretase (BACE-1) have been identified using a virtual high-throughput screening approach. Structure-activity relationship studies revealed structural features important for inhibition. Docking studies suggest these inhibitors may bind within the BACE-1 active site through H-bonding interactions involving the catalytic aspartate residues.Entities:
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Year: 2009 PMID： 19854048 DOI： 10.1016/j.bmcl.2009.09.103
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823