Literature DB >> 1985404

Role of vitamin E in preventing the oxidation of low-density lipoprotein.

H Esterbauer1, M Dieber-Rotheneder, G Striegl, G Waeg.   

Abstract

The fatty acid composition, antioxidants, and the oxidation resistance of the low-density lipoproteins (LDL) from a number of different donors were determined. The oxidation resistance of LDL, as determined in vitro by the duration of the lag-phase in copper ion-induced oxidation, did not correlate with the alpha-tocopherol content of the LDL. By supplementating plasma with vitamin E, the alpha-tocopherol content of LDL could be increased from approximately 9 to 30 mol/mol LDL and also the oxidative resistance increased nearly linearly with increasing alpha-tocopherol content. The results indicate that alpha-tocopherol is an important, yet not the only parameter that determines the oxidation resistance of LDL.

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Year:  1991        PMID： 1985404     DOI： 10.1093/ajcn/53.1.314S

Source DB:  PubMed          Journal:  Am J Clin Nutr        ISSN： 0002-9165            Impact factor:   7.045


  60 in total

1.  Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids.

Authors:  J Neuzil; P K Witting; R Stocker
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

2.  l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.

Authors:  Toshio Hayashi; Packiasamy A R Juliet; Hisako Matsui-Hirai; Asaka Miyazaki; Akiko Fukatsu; Jun Funami; Akihisa Iguchi; Louis J Ignarro
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-12       Impact factor: 11.205

3.  Effect of LDL-apheresis on the pharmacokinetics of the lipophilic antilipidemic agent probucol.

Authors:  T Komura; K Takahara; M Sugano; A Fujinishi; H Tasaki; Y Nakashima; A Kuroiwa
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Jul-Sep       Impact factor: 2.441

4.  Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages.

Authors:  H Shige; T Ishikawa; M Suzukawa; M Nishiwaki; T Yamashita; K Nakajima; T Ito; K Higashi; M Ayaori; A Yonemura; P Nestel; H Nakamura
Journal:  Lipids       Date:  1998-12       Impact factor: 1.880

5.  Factors affecting resistance of low density lipoproteins to oxidation.

Authors:  O Ziouzenkova; S P Gieseg; P Ramos; H Esterbauer
Journal:  Lipids       Date:  1996-03       Impact factor: 1.880

6.  Absence of an effect of vitamin E on protein and lipid radical formation during lipoperoxidation of LDL by lipoxygenase.

Authors:  Douglas Ganini; Ronald P Mason
Journal:  Free Radic Biol Med       Date:  2014-08-01       Impact factor: 7.376

7.  [The effect of unsaturated dietary fatty acids on the distribution of cholesterol in individual lipoprotein fractions and on serum lipids of rats].

Authors:  M Kirchgessner; H P Roth; M Schliack
Journal:  Z Ernahrungswiss       Date:  1993-03

8.  Prevention of renal damage by alpha tocopherol in ischemia and reperfusion models of rats.

Authors:  Mustafa Cihat Avunduk; Talat Yurdakul; Esra Erdemli; Ayşe Yavuz
Journal:  Urol Res       Date:  2003-07-03

9.  Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content.

Authors:  D L Tribble; J J van den Berg; P A Motchnik; B N Ames; D M Lewis; A Chait; R M Krauss
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

10.  Oxidized low-density lipoproteins impair endothelial function by inhibiting non-genomic action of thyroid hormone-mediated nitric oxide production in human endothelial cells.

Authors:  Roberto Vicinanza; Giuseppe Coppotelli; Carolina Malacrino; Tiziana Nardo; Barbara Buchetti; Luisa Lenti; Francesco S Celi; Susanna Scarpa
Journal:  Thyroid       Date:  2013-02       Impact factor: 6.568
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