BACKGROUND: Predictors of outcome have not been established for pediatric visceral and body wall nonrhabdomyosarcoma soft tissue sarcomas (NRSTS). METHODS: The study used a retrospective review of clinical features and outcome of 61 patients with visceral and body wall NRSTS evaluated at our institution between March 1962 and December 1999. RESULTS: Median age at diagnosis was 9.9 years (range, birth to 17.4 years). Tumors were greater than 5 cm in 43 (70%), high grade in 33 (54%), invasive in 25 (41%), and metastatic at presentation in 14 (23%) patients. Visceral tumors (n = 27) were more likely than body wall tumors (n = 34) to be greater than 5 cm (93% vs 53%; P < .001) and invasive (70% vs 18%; P < .001) and were less likely to be resected at diagnosis (44% vs 85%; P = .001). Estimated 10-year event-free survival (EFS) and overall survival (OS) for the entire cohort were 45.5% +/- 6.9% and 56.8% +/- 6.7%, respectively. The 10-year EFS and OS were better for patients with body wall sites than for those with visceral sites (61.8% +/- 8.5% and 67.5% +/- 8.2% vs 24.2% +/- 9.4% and 43.0% +/- 10.3%; P = .004 and P = .004). The 10-year estimated cumulative incidence (CI) of local recurrence was higher for patients with visceral sites than for those with body wall sites (64.3% +/- 9.8% vs 26.5% +/- 7.7%; P = .004), whereas CI of distant recurrence was similar for the 2 sites (15.2% +/- 7.2% vs 23.5% +/- 7.4%; P = .39). CONCLUSIONS: Pediatric patients with visceral NRSTS are more likely to have invasive, large, and unresectable tumors compared to those with body wall tumors. More than two thirds of visceral NRSTS recur locally, and fewer than half of patients with visceral tumors survive.
BACKGROUND: Predictors of outcome have not been established for pediatric visceral and body wall nonrhabdomyosarcoma soft tissue sarcomas (NRSTS). METHODS: The study used a retrospective review of clinical features and outcome of 61 patients with visceral and body wall NRSTS evaluated at our institution between March 1962 and December 1999. RESULTS: Median age at diagnosis was 9.9 years (range, birth to 17.4 years). Tumors were greater than 5 cm in 43 (70%), high grade in 33 (54%), invasive in 25 (41%), and metastatic at presentation in 14 (23%) patients. Visceral tumors (n = 27) were more likely than body wall tumors (n = 34) to be greater than 5 cm (93% vs 53%; P < .001) and invasive (70% vs 18%; P < .001) and were less likely to be resected at diagnosis (44% vs 85%; P = .001). Estimated 10-year event-free survival (EFS) and overall survival (OS) for the entire cohort were 45.5% +/- 6.9% and 56.8% +/- 6.7%, respectively. The 10-year EFS and OS were better for patients with body wall sites than for those with visceral sites (61.8% +/- 8.5% and 67.5% +/- 8.2% vs 24.2% +/- 9.4% and 43.0% +/- 10.3%; P = .004 and P = .004). The 10-year estimated cumulative incidence (CI) of local recurrence was higher for patients with visceral sites than for those with body wall sites (64.3% +/- 9.8% vs 26.5% +/- 7.7%; P = .004), whereas CI of distant recurrence was similar for the 2 sites (15.2% +/- 7.2% vs 23.5% +/- 7.4%; P = .39). CONCLUSIONS: Pediatric patients with visceral NRSTS are more likely to have invasive, large, and unresectable tumors compared to those with body wall tumors. More than two thirds of visceral NRSTS recur locally, and fewer than half of patients with visceral tumors survive.
Authors: Alexander Stojadinovic; Denis H Y Leung; Peter Allen; Jonathan J Lewis; David P Jaques; Murray F Brennan Journal: J Clin Oncol Date: 2002-11-01 Impact factor: 44.544
Authors: C B Pratt; A S Pappo; P Gieser; J J Jenkins; A Salzbergdagger; J Neff; B Rao; D Green; P Thomas; R Marcus; D Parham; H Maurer Journal: J Clin Oncol Date: 1999-04 Impact factor: 44.544
Authors: Sheri L Spunt; D Ashley Hill; Alison M Motosue; Catherine A Billups; Alvida M Cain; Bhaskar N Rao; Charles B Pratt; Thomas E Merchant; Alberto S Pappo Journal: J Clin Oncol Date: 2002-08-01 Impact factor: 44.544
Authors: Peter W T Pisters; Raphael E Pollock; Valerae O Lewis; Alan W Yasko; Janice N Cormier; Paula M Respondek; Barry W Feig; Kelly K Hunt; Patrick P Lin; Gunar Zagars; Caimiao Wei; Matthew T Ballo Journal: Ann Surg Date: 2007-10 Impact factor: 12.969
Authors: Alessandro Gronchi; Paolo G Casali; Marco Fiore; Luigi Mariani; Salvatore Lo Vullo; Rossella Bertulli; Maurizio Colecchia; Laura Lozza; Patrizia Olmi; Mario Santinami; Juan Rosai Journal: Cancer Date: 2004-06-01 Impact factor: 6.860
Authors: R Peto; M C Pike; P Armitage; N E Breslow; D R Cox; S V Howard; N Mantel; K McPherson; J Peto; P G Smith Journal: Br J Cancer Date: 1977-01 Impact factor: 7.640
Authors: John T Lucas; Israel Fernandez-Pineda; Christopher L Tinkle; Michael W Bishop; Sue C Kaste; Rajiv Heda; Andrew M Davidoff; Matthew J Krasin Journal: Pract Radiat Oncol Date: 2017-04-26