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Literature DB >> 19853663

Defining the chromatin landscape in demyelinating disorders.

Abstract

An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression. This review describes the chromatin landscape defining oligodendrocyte progenitor differentiation during development and remyelination. We shall discuss the current knowledge regarding modifications of chromatin components during the progression of progenitors into myelinating cells and discuss the potential contribution of histone variants, microRNAs, and DNA methylation. We shall also briefly address how changes to this chromatin landscape can disturb this natural progression and alter the capacity to remyelinate. (c) 2009. Published by Elsevier Inc.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Chromatin

Year: 2009 PMID： 19853663 PMCID： PMC2874074 DOI： 10.1016/j.nbd.2009.10.014

Source DB: PubMed Journal: Neurobiol Dis ISSN： 0969-9961 Impact factor: 5.996

94 in total

1. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1.

Authors: B D Strahl; S D Briggs; C J Brame; J A Caldwell; S S Koh; H Ma; R G Cook; J Shabanowitz; D F Hunt; M R Stallcup; C D Allis
Journal: Curr Biol Date: 2001-06-26 Impact factor: 10.834

Review 2. Histone variants: deviants?

Authors: Rohinton T Kamakaka; Sue Biggins
Journal: Genes Dev Date: 2005-02-01 Impact factor: 11.361

3. Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.

Authors: Sharmistha Pal; Sheethal N Vishwanath; Hediye Erdjument-Bromage; Paul Tempst; Saïd Sif
Journal: Mol Cell Biol Date: 2004-11 Impact factor: 4.272

Review 4. Epigenetics and the nervous system.

Authors: Mark F Mehler
Journal: Ann Neurol Date: 2008-12 Impact factor: 10.422

Review 5. Is there a code embedded in proteins that is based on post-translational modifications?

Authors: Robert J Sims; Danny Reinberg
Journal: Nat Rev Mol Cell Biol Date: 2008-09-11 Impact factor: 94.444

Review 6. Histone arginine methylation and its dynamic regulation.

Authors: Joanna Wysocka; C David Allis; Scott Coonrod
Journal: Front Biosci Date: 2006-01-01

7. Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination.

Authors: S A Shields; J M Gilson; W F Blakemore; R J Franklin
Journal: Glia Date: 1999-10 Impact factor: 7.452

8. Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings.

Authors: Mireya Marin-Husstege; Ye He; Jiadong Li; Toru Kondo; Fred Sablitzky; Patrizia Casaccia-Bonnefil
Journal: Glia Date: 2006-09 Impact factor: 7.452

9. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.

Authors: Menno P Creyghton; Styliani Markoulaki; Stuart S Levine; Jacob Hanna; Michael A Lodato; Ky Sha; Richard A Young; Rudolf Jaenisch; Laurie A Boyer
Journal: Cell Date: 2008-11-06 Impact factor: 41.582

10. Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression.

Authors: Sujun Hua; Caleb B Kallen; Ruby Dhar; Maria T Baquero; Christopher E Mason; Beth A Russell; Parantu K Shah; Jiang Liu; Andrey Khramtsov; Maria S Tretiakova; Thomas N Krausz; Olufunmilayo I Olopade; David L Rimm; Kevin P White
Journal: Mol Syst Biol Date: 2008-04-15 Impact factor: 11.429

4 in total