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Literature DB >> 19853629

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.

Panayotis K Thanos¹, Rahila Habibi, Michael Michaelides, Ujval B Patel, Katherine Suchland, Brenda J Anderson, John K Robinson, Gene-Jack Wang, David K Grandy, Nora D Volkow.

Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine. Published by Elsevier B.V.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19853629 PMCID： PMC2815086 DOI： 10.1016/j.bbr.2009.10.020

Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332

30 in total

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5. Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists.

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Review 6. The dopamine D(4) receptor: one decade of research.

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10. Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation.

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Journal: Front Pharmacol Date: 2017-12-21 Impact factor: 5.810