| Literature DB >> 19853606 |
Mihyun H Bae1, Gregory B Bissonette, Wendy M Mars, George K Michalopoulos, Cristian L Achim, Didier A Depireux, Elizabeth M Powell.
Abstract
Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, reverses the seizure behavior and stabilizes the spontaneous electroencephalogram activity. The perinatal intervention provides a pathway to reverse potential birth defects and ameliorate seizures in the adult.Entities:
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Year: 2009 PMID： 19853606 PMCID： PMC2812579 DOI： 10.1016/j.expneurol.2009.10.011
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330