| Literature DB >> 19853563 |
Tobias Langenhan1, Simone Prömel, Lamia Mestek, Behrooz Esmaeili, Helen Waller-Evans, Christian Hennig, Yuji Kohara, Leon Avery, Ioannis Vakonakis, Ralf Schnabel, Andreas P Russ.
Abstract
Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19853563 PMCID： PMC2819344 DOI： 10.1016/j.devcel.2009.08.008
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270