| Literature DB >> 19853488 |
Noralane M Lindor1, Ping Yang, Ilonka Evans, Karen Schowalter, Mariza De Andrade, Jia Li, Elysia Jeavons, Gloria Peterson, Steve Gallinger, Bharati Bapat, John Hopper, Jeremy Jass, Mark Jenkins, Allyson Templeton, John Potter, Polly A Newcomb, Loic Lemarchand, John Grove, Robert Haile, John Baron, Daniela Seminara, Paul Limburg, Stephen N Thibodeau.
Abstract
In a previous study, alpha-1-antitrypsin (A1AT) deficiency alleles were found to be over represented among individuals with microsatellite unstable (MSI-high) colorectal cancers, and this was most significant in former or current smokers. We evaluated this association in a larger case-control study, stratified by microsatellite instability phenotypes. Concordant with prior observations, gender (female) and smoking history were positively associated with colorectal cancers having an MSI-high phenotype. No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype. Copyright (c) 2009 Elsevier Inc. All rights reserved.Entities:
Mesh：
Year: 2009 PMID： 19853488 PMCID： PMC2818220 DOI： 10.1016/j.ymgme.2009.09.010
Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797