| Literature DB >> 19853442 |
L'ubos Remen1, Olivier Bezençon, Sylvia Richard-Bildstein, Daniel Bur, Lars Prade, Olivier Corminboeuf, Christoph Boss, Corinna Grisostomi, Thierry Sifferlen, Panja Strickner, Patrick Hess, Stéphane Delahaye, Alexander Treiber, Thomas Weller, Christoph Binkert, Beat Steiner, Walter Fischli.
Abstract
New classes of de novo designed renin inhibitors are reported. Some of these compounds display excellent in vitro and in vivo activities toward human renin in a TGR model. The synthesis of these new types of mono- and bicyclic scaffolds are reported, and properties of selected compounds discussed.Entities:
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Year: 2009 PMID： 19853442 DOI： 10.1016/j.bmcl.2009.09.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823