BACKGROUND: Cardiomyocytes cytoarchitecture changes caused by transthoracic countershocks have been focused recently. We aimed to evaluate the effects of electrical discharge application in the mitochondria structure in atrial myocardium of rats. METHODS: An electrical cardioverter was adapted to small rodent animals for our research. Electrical discharges were applied to the precordial region of 30 albino rats: (1) control group - animals that remained on resting period and were afterwards sacrificed; (2) electrical discharge group - animals that remained on resting period, followed by ten electrical discharges of 300 mV and sacrificed, and; (3) electrical post-discharge group - animals that remained on a resting period and received ten electrical discharges like the electrical discharge group, but were sacrificed seven days subsequently. We examined liver, adrenal and left atrium tissue fragments of the three groups. RESULTS: It was observed in control and post-discharge groups a normal cellular structure aspect with preserved architecture of cardiomyocytes and continuous sarcoplasmic membrane integrity. On the other hand, cardiac muscle fibers with mitochondrial edema and lysis occurred in the discharge group. Glycogen and adrenal lipids were not depleted in all groups. CONCLUSION: These data suggest that transthoracic electrical discharges induce mitochondrial injuries in atrial cardiac cells of rats.
BACKGROUND: Cardiomyocytes cytoarchitecture changes caused by transthoracic countershocks have been focused recently. We aimed to evaluate the effects of electrical discharge application in the mitochondria structure in atrial myocardium of rats. METHODS: An electrical cardioverter was adapted to small rodent animals for our research. Electrical discharges were applied to the precordial region of 30 albino rats: (1) control group - animals that remained on resting period and were afterwards sacrificed; (2) electrical discharge group - animals that remained on resting period, followed by ten electrical discharges of 300 mV and sacrificed, and; (3) electrical post-discharge group - animals that remained on a resting period and received ten electrical discharges like the electrical discharge group, but were sacrificed seven days subsequently. We examined liver, adrenal and left atrium tissue fragments of the three groups. RESULTS: It was observed in control and post-discharge groups a normal cellular structure aspect with preserved architecture of cardiomyocytes and continuous sarcoplasmic membrane integrity. On the other hand, cardiac muscle fibers with mitochondrial edema and lysis occurred in the discharge group. Glycogen and adrenal lipids were not depleted in all groups. CONCLUSION: These data suggest that transthoracic electrical discharges induce mitochondrial injuries in atrial cardiac cells of rats.
Authors: G H Bardy; F E Marchlinski; A D Sharma; S J Worley; R M Luceri; R Yee; B D Halperin; C L Fellows; T S Ahern; D A Chilson; D L Packer; D J Wilber; T A Mattioni; R Reddy; R A Kronmal; R Lazzara Journal: Circulation Date: 1996-11-15 Impact factor: 29.690
Authors: José R Cisternas; Vitor E Valenti; Thales B Alves; Celso Ferreira; Márcio Petenusso; João R Breda; Adilson C Pires; Nadir Tassi; Luiz Carlos de Abreu Journal: Int Arch Med Date: 2010-01-27
Authors: Marcelo Ferreira; Paulo Roberto Santos-Silva; Luiz Carlos de Abreu; Vitor E Valenti; Vanessa Crispim; Caio Imaizumi; Celso Ferreira Filho; Neif Murad; Adriano Meneghini; Andrés R Pérez Riera; Tatiana Dias de Carvalho; Luiz Carlos Marques Vanderlei; Erica E Valenti; José R Cisternas; Oseas F Moura Filho; Celso Ferreira Journal: Sports Med Arthrosc Rehabil Ther Technol Date: 2010-08-03
Authors: Marcelo Ferreira; Vitor E Valenti; Jose R Cisternas; Celso Ferreira; Adriano Meneghini; Celso Ferreira Filho; João R Breda; João A Correa; Carlos Bandeira de Mello Monteiro; Hugo Macedo Junior; Neif Murad; Luiz Carlos de Abreu Journal: Int Arch Med Date: 2011-01-22