Literature DB >> 19852497

A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands.

Trine P Petersen1, Andreas Ritzén, Trond Ulven.   

Abstract

A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.

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Year:  2009        PMID: 19852497     DOI: 10.1021/ol902101c

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

Review 1.  Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic.

Authors:  Chinmay A Shukla; Amol A Kulkarni
Journal:  Beilstein J Org Chem       Date:  2017-05-19       Impact factor: 2.883

Review 2.  Understanding flow chemistry for the production of active pharmaceutical ingredients.

Authors:  Anand S Burange; Sameh M Osman; Rafael Luque
Journal:  iScience       Date:  2022-02-10
  2 in total

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