Hemoprotein formation in yeast. VII. Genetic analysis of pleiotropic mutants affected in the response to glucose repression and anoxia.

Genetical analysis of three pleiotropic mutants with changed regulation of hemoprotein level was performed. It was proved that single recessive mutations cgr4, cas1 and cgh1 are responsible for simultaneous changes of catalase T, cytochrome c oxidase and of some other enzyme levels, in glucose repression conditions. Two mutations cgr4 and cas1, responsible for glucose resistance of hemoprotein formation in aerobic conditions enable also anaerobic synthesis of catalase T. Mutation cgh1 causing hypersensitivity of several respiratory enzymes to glucose repression is partly epistatic to cas1 and cgr4 mutations.