OBJECTIVES: We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies. METHODS: At the baseline of the Women's Health Initiative Observational Study (1994-1998), participants reported information about intentional weight loss episodes in the past 20 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) among 81,219 women for associations between past intentional weight loss and risk of developing non-Hodgkin lymphoma (NHL), leukemia, and multiple myeloma during an average 9.9 years of follow-up. RESULTS: The risk of NHL was associated with having lost a large maximum amount of weight (> or =50 pounds, HR = 1.68, 95% CI 1.13-2.50). NHL risk also varied by the frequency of intentional weight loss; women had increased risk if they lost 50 pounds or more > or =3 times (HR = 1.97, 95% CI 0.93-4.16; p trend by frequency = 0.09) or 20-49 pounds > or =3 times (HR = 1.55, 95% CI 1.00-2.40; p trend = 0.05), but there was no risk associated with smaller amounts of weight loss (10-19 pounds > or =3 times, HR = 0.78, 95% CI 0.46-1.33). These associations persisted with adjustment for body mass index at different ages. We observed non-significant associations of similar magnitude for multiple myeloma, but past intentional weight loss episodes were not associated with leukemia. CONCLUSION: Further assessment of intentional weight loss as a possible risk factor for lymphomas may provide insight into the etiology of these cancers.
OBJECTIVES: We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies. METHODS: At the baseline of the Women's Health Initiative Observational Study (1994-1998), participants reported information about intentional weight loss episodes in the past 20 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) among 81,219 women for associations between past intentional weight loss and risk of developing non-Hodgkin lymphoma (NHL), leukemia, and multiple myeloma during an average 9.9 years of follow-up. RESULTS: The risk of NHL was associated with having lost a large maximum amount of weight (> or =50 pounds, HR = 1.68, 95% CI 1.13-2.50). NHL risk also varied by the frequency of intentional weight loss; women had increased risk if they lost 50 pounds or more > or =3 times (HR = 1.97, 95% CI 0.93-4.16; p trend by frequency = 0.09) or 20-49 pounds > or =3 times (HR = 1.55, 95% CI 1.00-2.40; p trend = 0.05), but there was no risk associated with smaller amounts of weight loss (10-19 pounds > or =3 times, HR = 0.78, 95% CI 0.46-1.33). These associations persisted with adjustment for body mass index at different ages. We observed non-significant associations of similar magnitude for multiple myeloma, but past intentional weight loss episodes were not associated with leukemia. CONCLUSION: Further assessment of intentional weight loss as a possible risk factor for lymphomas may provide insight into the etiology of these cancers.
Authors: Geoffrey C Kabat; Mimi Y Kim; Jennifer W Bea; Kerstin L Edlefsen; Lucile L Adams-Campbell; Anneclaire J De Roos; Thomas E Rohan Journal: Cancer Epidemiol Date: 2011-08-04 Impact factor: 2.984
Authors: Zongjian Zhu; Weiqin Jiang; Jarrod H Zacher; Elizabeth S Neil; John N McGinley; Henry J Thompson Journal: Cancer Prev Res (Phila) Date: 2012-01-13
Authors: Lauren R Teras; Cari M Kitahara; Brenda M Birmann; Patricia A Hartge; Sophia S Wang; Kim Robien; Alpa V Patel; Hans-Olov Adami; Elisabete Weiderpass; Graham G Giles; Pramil N Singh; Michael Alavanja; Laura E Beane Freeman; Leslie Bernstein; Julie E Buring; Graham A Colditz; Gary E Fraser; Susan M Gapstur; J Michael Gaziano; Edward Giovannucci; Jonathan N Hofmann; Martha S Linet; Gila Neta; Yikyung Park; Ulrike Peters; Philip S Rosenberg; Catherine Schairer; Howard D Sesso; Meir J Stampfer; Kala Visvanathan; Emily White; Alicja Wolk; Anne Zeleniuch-Jacquotte; Amy Berrington de González; Mark P Purdue Journal: Br J Haematol Date: 2014-05-23 Impact factor: 6.998
Authors: Jonathan N Hofmann; Steven C Moore; Unhee Lim; Yikyung Park; Dalsu Baris; Albert R Hollenbeck; Charles E Matthews; Todd M Gibson; Patricia Hartge; Mark P Purdue Journal: Am J Epidemiol Date: 2013-03-29 Impact factor: 4.897
Authors: Brenda M Birmann; Gabriella Andreotti; Anneclaire J De Roos; Nicola J Camp; Brian C H Chiu; John J Spinelli; Nikolaus Becker; Véronique Benhaim-Luzon; Parveen Bhatti; Paolo Boffetta; Paul Brennan; Elizabeth E Brown; Pierluigi Cocco; Laura Costas; Wendy Cozen; Silvia de Sanjosé; Lenka Foretová; Graham G Giles; Marc Maynadié; Kirsten Moysich; Alexandra Nieters; Anthony Staines; Guido Tricot; Dennis Weisenburger; Yawei Zhang; Dalsu Baris; Mark P Purdue Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-02-21 Impact factor: 4.254
Authors: Victoria L Stevens; Eric J Jacobs; Alpa V Patel; Juzhong Sun; Marjorie L McCullough; Peter T Campbell; Susan M Gapstur Journal: Am J Epidemiol Date: 2015-07-23 Impact factor: 4.897
Authors: Dong Hoon Lee; NaNa Keum; Leandro F M Rezende; Fred K Tabung; SungEun Hong; Edward L Giovannucci Journal: Cancer Causes Control Date: 2021-06-05 Impact factor: 2.506
Authors: Molly E Schwalb; Stephanie A Smith-Warner; Jianrui Hou; Thomas E Rohan; Linda Snetselaar; Juhua Luo; Jeanine M Genkinger Journal: Am J Epidemiol Date: 2022-05-20 Impact factor: 5.363
Authors: Catherine R Marinac; Brenda M Birmann; I-Min Lee; Bernard A Rosner; Mary K Townsend; Edward Giovannucci; Timothy R Rebbeck; Julie E Buring; Graham A Colditz Journal: Br J Cancer Date: 2018-03-12 Impact factor: 7.640