BACKGROUND: The acute kidney injury (AKI) is a complex disease for which there is no accepted standard definition nowadays. The Acute Kidney Injury Network (AKIN) represents an attempt to standardize the criteria for diagnosis and staging of acute renal dysfunction based on recently published RIFLE criteria, that means, (Risk, Injury, Failure, Loss, and End-stage kidney disease). OBJECTIVES: To evaluate the incidence and associated mortality of AKI in patients submitted to on-pump coronary artery bypass graft surgery (on-pump CABG). METHODS: A total of 817 patients were divided into two groups: negative AKI (-), with 421 patients (51.5%), and positive AKI (+), with 396 patients (48.5%). Increase of 0.3 mg/dL in creatinine or of 50% in creatinine's basal value was considered as AKI. RESULTS: The rate of patient's mortality with or without AKI within 30 days after cardiac surgery was 12.6% and 1.4%, respectively (p<0.0001). In a multivariate logistic regression model, AKI after on-pump CABG was an independent predictor of death within 30 days (OR=6.7; p=0.0002). This group of patients presented a longer period of permanency in intensive care unit (ICU) [median 2 days (2 to 3) versus 3 days (2 to 5); p=0.0001] and a bigger proportion of patients with prolonged permanence in intensive care (>14 days) (14 versus 2%; p=0.0001). CONCLUSION: In the studied population, even a discrete alteration in renal function, based on AKIN criteria, was an independent predictor of death in 30 days after on-pump CABG.
BACKGROUND: The acute kidney injury (AKI) is a complex disease for which there is no accepted standard definition nowadays. The Acute Kidney Injury Network (AKIN) represents an attempt to standardize the criteria for diagnosis and staging of acute renal dysfunction based on recently published RIFLE criteria, that means, (Risk, Injury, Failure, Loss, and End-stage kidney disease). OBJECTIVES: To evaluate the incidence and associated mortality of AKI in patients submitted to on-pump coronary artery bypass graft surgery (on-pump CABG). METHODS: A total of 817 patients were divided into two groups: negative AKI (-), with 421 patients (51.5%), and positive AKI (+), with 396 patients (48.5%). Increase of 0.3 mg/dL in creatinine or of 50% in creatinine's basal value was considered as AKI. RESULTS: The rate of patient's mortality with or without AKI within 30 days after cardiac surgery was 12.6% and 1.4%, respectively (p<0.0001). In a multivariate logistic regression model, AKI after on-pump CABG was an independent predictor of death within 30 days (OR=6.7; p=0.0002). This group of patients presented a longer period of permanency in intensive care unit (ICU) [median 2 days (2 to 3) versus 3 days (2 to 5); p=0.0001] and a bigger proportion of patients with prolonged permanence in intensive care (>14 days) (14 versus 2%; p=0.0001). CONCLUSION: In the studied population, even a discrete alteration in renal function, based on AKIN criteria, was an independent predictor of death in 30 days after on-pump CABG.
Authors: Márcio Campos Sampaio; Carlos Alberto Gonçalves Máximo; Carolina Moreira Montenegro; Diandro Marinho Mota; Tatiana Rocha Fernandes; Antonio Carlos Mugayar Bianco; Celso Amodeo; Antonio Carlos Cordeiro Journal: Arq Bras Cardiol Date: 2013-06-11 Impact factor: 2.000
Authors: Wim Vandenberghe; Sofie Gevaert; John A Kellum; Sean M Bagshaw; Harlinde Peperstraete; Ingrid Herck; Johan Decruyenaere; Eric A J Hoste Journal: Cardiorenal Med Date: 2015-12-19 Impact factor: 2.041
Authors: Carlos Alberto Dos Santos; Marcos Aurélio Barboza de Oliveira; Antônio Carlos Brandi; Paulo Henrique Husseini Botelho; Josélia de Cássia Menin Brandi; Marcio Antônio Dos Santos; Moacir Fernandes de Godoy; Domingo Marcolino Braile Journal: Rev Bras Cir Cardiovasc Date: 2014 Oct-Dec
Authors: Rodrigo Cartin-Ceba; Markos Kashiouris; Maria Plataki; Daryl J Kor; Ognjen Gajic; Edward T Casey Journal: Crit Care Res Pract Date: 2012-11-26