| Literature DB >> 19850475 |
Zhi Zhang1, Rui He, Kun Yan, Qian-ni Guo, Yun-guo Lu, Xu-xia Wang, Hao Lei, Zao-ying Li.
Abstract
5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R(1)) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane.Entities:
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Year: 2009 PMID： 19850475 DOI： 10.1016/j.bmcl.2009.10.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823