| Literature DB >> 19850309 |
Aramesh Saremi1, Matthew Allison, Dominic Ditomasso, Ling Ge, Robert Anderson, Tom E Moritz, William Duckworth, Carlos Abraira, Peter D Reaven.
Abstract
Although the association between inflammation and hepatic fat is fairly established, it remains unclear whether this association is independent of general measures of obesity and standard cardiovascular risk factors. Therefore, the aim of this study was to investigate the contribution of hepatic steatosis as an independent predictor of chronic inflammation in 281 subjects with type 2 diabetes mellitus. Reduced hepatic steatosis significantly (P < .01) correlated with C-reactive protein (r = -0.16) and adiponectin (r = 0.23). The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors. (c) 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19850309 PMCID： PMC2823936 DOI： 10.1016/j.metabol.2009.07.041
Source DB: PubMed Journal: Metabolism ISSN： 0026-0495 Impact factor: 8.694