OBJECTIVE: To study vascular endothelial growth factor (VEGF) and its soluble receptors sVEGFR-1 and -2 in autism. DESIGN AND METHODS: We measured serum levels of angiogenic molecules in 22 patients with severe autism and 28 controls. RESULTS: Patients and controls had similar sVEGFR-2 levels, but VEGF levels were lower and sVEGFR-1 higher in patients with autism. CONCLUSION: The imbalance between VEGF and its receptor sVEGFR-1 may be involved in the pathophysiology of autism. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To study vascular endothelial growth factor (VEGF) and its soluble receptors sVEGFR-1 and -2 in autism. DESIGN AND METHODS: We measured serum levels of angiogenic molecules in 22 patients with severe autism and 28 controls. RESULTS:Patients and controls had similar sVEGFR-2 levels, but VEGF levels were lower and sVEGFR-1 higher in patients with autism. CONCLUSION: The imbalance between VEGF and its receptor sVEGFR-1 may be involved in the pathophysiology of autism. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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