| Literature DB >> 19848610 |
Martin P Grobusch1, Julian J Gabor, John J Aponte, Norbert G Schwarz, Marc Poetschke, Jenny Doernemann, Katharina Schuster, Kai B Koester, Katharina Profanter, Lea B Borchert, Florian Kurth, Peter Pongratz, Saadou Issifou, Bertrand Lell, Peter G Kremsner.
Abstract
In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 months. In the intention-to-treat population, the protective efficacy against all malaria episodes was -18.0 (95% confidence interval, -97.4 to 29.5; P = .529). The protective efficacy against first or only anemia episode was -45.3 (95% confidence interval, -234.5 to 36.3; P=.375). The protective efficacies were negative and were not statistically significant. These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants. Clinical trials registration. NCT00167843.Entities:
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Year: 2009 PMID： 19848610 DOI： 10.1086/647990
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226